PerkinElmer
  • 研究领域
  • 药物研发及发展

高通量和表型筛选

集通量与表型于一体为药物研发提供理想解决方案

为了更快地将药物上市销售,您需要加快上下游工作流程。我司提供的筛选解决方案是实现以上要求的重要因素:凭借最先进的成像和检测仪器、试验技术、试剂、通用自动化系统和强大的信息学解决方案,确保一致、准确的,具有明确生理相关性结果的获得——通过深度的多维分析,为您的研究提供更多发现。借助完整的配套仪器、试剂和信息学解决方案,将以表型或靶标为基础的筛选进行有效放大,从而在小范围的集中筛选或高通量筛选中发现苗头和先导化合物:

  • 明确分子靶标的筛选试验
  • 基于细胞模型的高内涵筛选
  • 针对微组织和3D培养细胞的高内涵分析
  • 正交试验和二次筛选
  • 选择性筛选
  • 大容量数据捕获和快速分析

Applications and Techniques

Microplate Reader Assays

Whether you are working on basic research, assay development, or high-throughput screening, you need accurate data you can trust, every time. Our multimode microplate readers, Alpha®, LANCE® Ultra TR-FRET, DELFIA® TRF, and Luminescence assays and microplates provide excellent sensitivity and performance, and can help you save time and headaches. We offer a wide range of biochemical and cell-based screening assays, all of which are validated on our microplate readers, so you can be confident that you will get reliable results, service and support.

For research use only. Not for use in diagnostic procedures.

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高内涵筛选与分析

High-Content Analysis (HCA) or High-Content Screening (HCS) combines high-throughput automated imaging and analysis to extract quantitative multi-parametric data at the single-cell level. Originally developed as a complementary technology to traditional biochemical high-throughput screening (HTS) in drug discovery, today high-content screening is established in a far broader area of the life science space as an unbiased imaging method to assess cellular function.

High-content screening offers a number of advantages over traditional techniques:

  • More information from cellular samples
    Fully automated imaging and unbiased quantitative image analysis exploits the full potential of microscopy, improving your lab’s throughput and productivity.
  • More meaningful results
    Screening can be performed in more physiologically and biologically relevant systems than in classical biochemical assays.
  • More questions answered simultaneously
    Data sets are more information-rich compared to non-imaging read-outs, allowing a number of questions to be answered simultaneously.

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筛选分析

Companies that most quickly and accurately identify key drug discovery parameters will win the race to promote the most appropriate targets and develop medicines to affect them. PerkinElmer Screening and Lead Discovery solutions let scientists manage screening data from raw data import, QC, analytics and visualization to publication and management.

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Featured Products

药物开发试剂

Drug discovery is a complex, costly and time-consuming undertaking. For research scientists, screening potential candidates is where the journey begins.

Your job is to move from target to hit to candidate quickly and efficiently – with as little wasted resources as possible. Our drug discovery screening reagents do just that. Whether you are doing high throughput screening or focused screening, we offer a wide range of validated reagents and kits in Alpha chemiluminescent, LANCE® TR-FRET, DELFIA® TRF, and other assay technologies to suit you screening assay needs.

Accelerate your workflow with our drug discovery screening reagents while getting consistent, accurate and physiologically relevant results.

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微孔板

A microplate is a critical part of your discovery process.  Microplates have the capability to generate valuable, information-rich data that bring great insights into discovery screening.

Microplate planarity and inaccurate data collection are common issues caused by microplates that are not carefully designed for the unique challenges of sample screening which can result in missed data points, sample re-screening, missed project timelines, and ultimately higher costs.

Drawing on many years of experience in high throughput screening, PerkinElmer’s expert team has developed microplates that address the most common screening challenges. Our microplates have been engineered to deliver the highest quality data for high throughput screening as well as imaging applications.

  • Footprint dimensions meet the SBS industry standard, guaranteeing compatibility with microplate-based instrumentation
  • Carefully monitored microplate planarity to ensure superb data and image acquisition
  • Custom microplate services including barcoding, custom packaging, as well as plate surface coatings to fit your application
  • Full range of validated reagents and instruments to compliment microplates

By using PerkinElmer’s microplates specifically engineered for high throughput screening and imaging applications, you can be confident that you’ll acquire high quality results providing more information-rich data and experience fewer re-screens reducing your overall screening costs.

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自动化和液体处理仪器

With dedicated workstations designed for a diverse variety of applications, along with the ability to customize liquid handling workstations based on your needs, our innovative automated liquid handling solutions enable you to minimize errors, reduce hands-on time, and increase throughput and reproducibility. With flexibility in throughput, capacity and dynamic volume range, high quality manufacturing standards, and outstanding customer service and support, we offer solutions optimized to meet your laboratory’s needs.

From benchtop application-specific workstations to complex customized integrated solutions our liquid handing portfolio automates your science.

For research use only. Not for use in diagnostic procedures.

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PerkinElmer Signals Screening

Signals Screening is an intuitive, configurable, and flexible screening workflow processing engine on top of the unparalleled data visualization and analysis capabilities of TIBCO Spotfire. The initial offering of Signals Screening addresses three key drug discovery assays:
  • Basic Screening
  • High Content Screening (HCS)
  • Surface Plasmon Resonance (SPR)

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EnVision 2105 Multimode Plate Reader

The EnVision 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.

The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP). In addition, the Alpha 775 laser module is designed for plant assays.

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EnSight 多模式读板仪

The EnSight multimode plate reader combines labeled & image-based cytometry technologies in a single benchtop platform. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.

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Operetta CLS 高内涵分析系统

Uncover deep biological understanding in your everyday assays and innovative applications using the Operetta CLS high-content analysis system. Featuring a unique combination of technologies, the system delivers all the speed, sensitivity and resolution you need to reveal fine sub-cellular details. And with our simple, powerful Harmony 4.5 software, Operetta CLS lets you find even subtle phenotypic changes.

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Opera Phenix高内涵筛选系统

The Opera Phenix High Content Screening System is the premier confocal solution for today's most demanding high content applications. Drawing on over a decade of experience with the industry-leading Opera® High Content Screening System, the Opera Phenix is designed for high-throughput, phenotypic screening and assays involving complex disease models, such as live cells, primary cells and microtissues.

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