PerkinElmer与哈勃,为人类打磨一双慧眼
在历史长河中,人类对于头顶上这片星空的探索从公元前开始就从未停止过。古希腊先人用自己丰富的想象力和浪漫情怀为夜晚的星空划分出一个个星座,寄寓着一个个动人的神话故事。而现代人类早已不满足于用想象力去定义这浩瀚的宇宙,人们渴望着用自己的眼睛更真实地感知我们生活的宇宙空间。
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There is currently little to be done to cure people who suffer from traumatic brain injury (neurotrauma), but research groups headed by Dr. Brian Cummings and Dr. Aileen Anderson, professors at the Stem Cell Research Center at the University of California, Irvine, are hoping to use human neural stem cells (hNSCs) to promote recovery of neural function after injury.
Neurotrauma, or damage to the brain incurred from a severe head injury, can cause the loss of important central nervous system cells and produce mild to severe symptoms ranging from headaches, blurred vision and confusion to behavioral changes, memory loss and seizures. According to the National Institute of Neurological Disorders and Stroke (NIH), "Disabilities resulting from a TBI depend upon the severity of the injury, the location of the injury, and the age and general health of the individual."
""We needed a program that would allow us to quickly quantify large data sets with replicable results, and provide more accurate and consistent results than human-based quantification. For this reason, Volocity software has been critical in our work and we use it almost daily.""
It's generally believed that there is little that can be done to reverse the signs of brain injury, but the research groups headed by Dr. Cummings and Dr. Anderson are investigating how these lost cells may be partially replaced by transplanting multipotent human neural stem cells (hNSCs), a specialized subset of stem cells which can form cells of the nervous system. If the cells that are lost when neurotrauma occurs can be replaced by hNSCs, it may be possible to restore function after injury.
hNSCs can be derived from embryonic, fetal, or adult sources. Dr. Cummings and Dr. Anderson's research teams are investigating how different methods of deriving and culturing these cells might affect their ability to differentiate and multiply in vitro and to ultimately respond to the injured microenvironment in vivo. Because the therapeutic use of hNSCs in neurotrauma will require immunosuppressants to prevent rejection by the host's immune response, the team is also looking to understand how these drugs might impact the performance of hNSCs.
Such questions are studied using time-lapse imaging for tracking stem cell proliferation, migration and fate over days or weeks in vitro toreveal individual cell responses to inflammatory cues, differentiation factors, or drug treatments.
Because the accurate evaluation of human stem cell lineage and fate is essential for this research, Dr. Cummings and Dr. Anderson's research teams recognized the need for an efficient, automated method for analyzing the fate of hNSCs in vitro. To this end, they chose to use Volocity® 3D Image Analysis Software which enables them to reconstruct 3D images, identify specific cell markers and accurately distinguish between objects in overpopulated images.
"Our work required that we had an unbiased high-throughput quantification method," says Dr. Cummings. "We needed a program that would allow us to quickly quantify large data sets with replicable results, and provide more accurate and consistent results than human-based quantification. For this reason, Volocity software has been critical in our work and we use it almost daily."
For Research use only. Not for use in diagnostic procedures.在历史长河中,人类对于头顶上这片星空的探索从公元前开始就从未停止过。古希腊先人用自己丰富的想象力和浪漫情怀为夜晚的星空划分出一个个星座,寄寓着一个个动人的神话故事。而现代人类早已不满足于用想象力去定义这浩瀚的宇宙,人们渴望着用自己的眼睛更真实地感知我们生活的宇宙空间。
2019昆明国际肿瘤研究论坛在昆明顺利召开,本届会议邀请了国内外癌症研究领域顶尖的华人学者们齐聚一堂,共襄盛会,围绕“癌症基础研究和临床治疗”的主题,共同分享与探讨了癌症发生、发展和治疗的新知识和远见。
珀金埃尔默对创新的承诺是建立在公司的科学家和研究人员的伟大工作之上的,是他们的研究成果建立了珀金埃尔默在人类和环境健康领域的市场领先优势。
Milano-Bicocca大学环境科学系的Giovanni Baccolo博士和他的同事研究分析南极冰芯样品,重点在于分析包裹在冰中的大气矿物颗粒,俗称“尘埃”。
我是来自珀金埃尔默的ChemDraw,我为化学绘图代言!