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Apoptosis assays are a widely used application in High Content Analysis because of their central role in cancer research and immunology.
Cell cycle assays are applied in early toxicity testing and in screening for anti-cancer agents.
Cell differentiation is a multi-step procedure associated with the expression of a specific set of cellular markers in each step.
Analysis of cell migration is an important phenotypical assay of processes such as tumor metastasis, immune response and wound healing.
The accurate assessment of cell number and cell proliferation is useful in many high content assays.
Analysis of cell spreading is relevant to screening for inhibitors of cell adherence to a substrate.
Cytoskeletal rerarrangements occur in physiological events such as cell movement. Cytoskeletal defects are frequently associated with diseases such as cancer / metastasis and also cytotoxicity.
The ability to measure early indicators of toxicity is an essential part of drug discovery.
Traditionally an area for flow cytometry, many infection assays have been transferred from flow cytometry to imaging.
Image based analysis of lipid droplet formation is used in two application areas: predicting drug toxicity and metabolic diseases.
Regeneration of neurons represents a promising strategy for drugs targeted against neurodegenerative injuries and disorders such as Alzheimer’s and Parkinson’s disease.
Protein expression can be very easily quantified in High Content Analysis using either fluorescent protein tags or fluorescently labeled antibodies.
There are many image based approaches for studying receptor activation.
Reporter gene assays have easily measurable phenotypes that form the basis of sensitive, quantitative and reproducible assays of eukaryotic gene expression and regulation.
Image based High Content Analysis can support all signaling pathway assays which rely on the translocation of a fluorescently labeled signaling molecule.
Activation of transcription factors can be monitored by imaging as a translocation from the cytoplasm to the nucleus using antibodies for the transcription factors or fluorescent protein tags.