The cytoskeleton, a filamentous network of actin, tubulin and other protein components, is essential for cellular structure, maintenance, intracellular transport, cell division and many other functions.

Cytoskeletal rerarrangements occur in physiological events such as cell movement. Cytoskeletal defects are frequently associated with diseases such as cancer / metastasis and also cytotoxicity. Monitoring the cytoskeletal structure is a very sensitive High Content Analysis in many application areas.

Untreated cells – structured distribution of tubulin with high intensity near the nucleus and decreasing intensity near the plasma membrane. Re-arrangement of tubulin due to treatment with Demecolcin.