DNA Damage and FISH | Cellular Imaging & Analysis | Lab Products & Services | PerkinElmer
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DNA Damage and Fluorescence in situ Hybridization (FISH)

DNA damage and FISH

Fluorescence in situ hybridization (FISH) is a powerful technique for detecting RNA or DNA sequences in cells, tissues and tumors. FISH provides a unique link among the studies of cell biology, cytogenetics and molecular genetics. It uses fluorescent probes that only bind to the parts of the chromosome with which they show a high degree of sequence similarity.

High content analysis can be used to identify FISH signals in nuclei as fluorescent spots and can distinguish different samples bound to the chromosomes using different colored fluorescent probes.

Related Application Notes and Publications

Cell.com, "Identification of Gene Positioning Factors Using High-Throughput Imaging Mapping".

PLOS Genetics, "Identification of Genes That Promote or Antagonize Somatic Homolog Pairing Using a High-Throughput FISH–Based Screen".

For Research Use Only. Not for Use in Diagnostic Procedures.