Stem cell research has the potential to make a huge impact on a wide range of human health problems. Stem cell research could facilitate the development of new treatments for human diseases such as diabetes and Parkinson’s, aid the treatment and prevention of medical conditions resulting from abnormal cell division and cell differentiation, and enable the testing of new drugs without the need for animals or human testers. It could also provide a renewable source of replacement cells and tissues to treat diseases such as Alzheimer's disease, stroke, heart disease, osteoarthritis and rheumatoid arthritis.

HCS is a powerful technology to analyze stem cell differentiation efficiently under a large variety of conditions and over long periods of times. Scientists are able visualize and analyze complex cellular processes, identify and characterize cells in their various stages of development.

For this fast paced area of research, PerkinElmer provides state-of-the-art high content screening solutions to stem cell researchers all over the world. Our dedicated team of HCS specialists have an in-depth understanding of the imaging-based stem cell applications and will help you choose the right solution for your research requirements.

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Publications using PerkinElmer High-Content Screening Products

• Choudhary S, Pardo A, Rosinke R, Batra JK, Barth S and Verma RS. Targeting c-kit receptor in neuroblastomas and colorectal cancers using stem cell factor (SCF)-based recombinant bacterial toxins.Applied microbiology and biotechnology. 2016; 100(1):263-277, doi: 10.1007/s00253-015-6978-2.
• Costa V, Aigner S, Vukcevic M, Sauter E, Behr K, Ebeling M, Dunkley T, Friedlein A, Zoffmann S and Meyer CA. 2016. mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis. Cell Reports. 2016; 15(1):86-95,doi: 10.1016/j.celrep.2016.02.090.
• Hildebrand L, Rossbach B, Kühnen P, Gossen M, Kurtz A, Reinke P, Seemann P and Stachelscheid H. Generation of integration free induced pluripotent stem cells from fibrodysplasia ossificans progressiva (FOP) patients from urine samples.Stem Cell Research. 2016; 16(1):54-58, doi: 10.1016/j.scr.2015.11.017.
• Rossbach B, Hildebrand L, El-Ahmad L, Stachelscheid H, Reinke P and Kurtz A. Generation of a human induced pluripotent stem cell line from urinary cells of a healthy donor using an integration free vector. Stem Cell Research. 2016; 16(1):133-136, doi: 10.1016/j.scr.2015.12.021.
• Abdallah BM, Al-Shammary A, Skagen P, Dawud RA, Adjaye J, Aldahmash A and Kassem M. CD34 defines an osteoprogenitor cell population in mouse bone marrow stromal cells.Stem Cell Research. 2015; 15(2):449-458, doi: 10.1016/j.scr.2015.09.005.
• Ahmed SU, Carruthers R, Gilmour L, Yildirim S, Watts C and Chalmers AJ. Selective inhibition of parallel DNA damage response pathways optimizes radiosensitization of glioblastoma stem-like cells. Cancer Research. 2015; 75(20)4416-4428, doi: 10.1158/0008-5472.
• Andersen RK, Zaher W, Larsen KH, Ditzel N, Drews K, Wruck W, Adjaye J, Abdallah BM and Kassem M. Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells.Stem Cell Research & Therapy. 2015; 6:196,doi: 10.1186/s13287-015-0188-9.
• Antonczak A, Mullee L, Wang Y, Comartin D, Inoue T, Pelletier L and Morrison C. Opposing effects of pericentrin and microcephalin on the pericentriolar material regulate CHK1 activation in the DNA damage response. Oncogene. 2016; 35:2203-2010,doi: 10.1038/onc.2015.257.
• Aravindan S, Ramraj SK, Somasundaram ST and Aravindan N. Novel adjuvants from seaweed impede autophagy signaling in therapy-resistant residual pancreatic cancer. Journal of Biomedical Science. 2015; 22:28,doi: 10.1186/s12929-015-0132-4.
• Bader AM, Klose K, Bieback K, Korinth D, Schneider M, Seifert M, Choi Y-H, Kurtz A, Falk V and Stamm C. Hypoxic Preconditioning Increases Survival and Pro-Angiogenic Capacity of Human Cord Blood Mesenchymal Stromal Cells In Vitro.PloS One. 2015; 10(9):e0138477, doi: 10.1371/journal.pone.0138477.
• Brodarac A, Šarić T, Oberwallner B, Mahmoodzadeh S, Neef K, Albrecht J, Burkert K, Oliverio M, Nguemo F and Choi Y-H. Susceptibility of murine induced pluripotent stem cell-derived cardiomyocytes to hypoxia and nutrient deprivation. Stem Cell Research & Therapy. 2015; 6:83,doi: 10.1186/s13287-015-0057-6.
• Calder EL, Tchieu J, Steinbeck JA, Tu E, Keros S, Ying S-W, Jaiswal MK, Cornacchia D, Goldstein PA and Tabar V. Retinoic Acid-Mediated Regulation of GLI3 Enables EfficientMotoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation.The Journal of Neuroscience. 2015: 35(33):11462-11481,doi: 10.1523/JNEUROSCI.3046-14.2015.
• Celiz AD, Smith JG, Patel AK, Hook AL, Rajamohan D, George VT, Flatt L, Patel MJ, Epa VC and Singh T. Discovery of a novel polymer for human pluripotent stem cellexpansion and multilineage differentiation. Advanced Materials. 2015; 27(27):4006-4012, doi: 10.1002/adma.201501351.
• Chen L, Shi K, Frary CE, Ditzel N, Hu H, Qiu W and Kassem M. Inhibiting actindepolymerization enhances osteoblast differentiation and bone formation in humanstromal stem cells.Stem Cell Research. 2015; 15(2):281-289, doi: 10.1016/j.scr.2015.06.009.
• Ghaemi SR, Delalat B, Cetó X, Harding FJ, Tuke J and Voelcker NH. Synergistic influence of collagen I and BMP 2 drives osteogenic differentiation of mesenchymal stem cells: A cell microarray analysis.Acta Biomaterialia. 2015; 34:41-52, doi: 10.1016/j.actbio.2015.07.027.
• Hildebrand L, Seemann P, Kurtz A, Hecht J, Contzen J, Gossen M and Stachelscheid H. Selective cell targeting and lineage tracing of human induced pluripotent stem cells using recombinant avian retroviruses.Cellular and Molecular Life Sciences. 2015; 72(23):4671-4680, doi: 10.1007/s00018-015-1957-4.
• Kaufmann M, Schuffenhauer A, Fruh I, Klein J, Thiemeyer A, Rigo P, Gomez-Mancilla B, Heidinger-Millot V, Bouwmeester T and Schopfer U. High-Throughput Screening Using iPSC-Derived Neuronal Progenitors to Identify Compounds Counteracting Epigenetic Gene Silencing in Fragile X Syndrome. Journal of Biomolecular Screening. 2015; 20(9):1101-1111, doi: 10.1177/1087057115588287.
• Kiris E, Burnett JC, Nuss JE, Wanner LM, Peyser BD, Du HT, Gomba GY, Kota KP, Panchal RG and Gussio R. Src Family Kinase Inhibitors Antagonize the Toxicity of Multiple Serotypes of Botulinum Neurotoxin in Human Embryonic Stem Cell-Derived Motor Neurons. Neurotoxicity Research. 2015; 27(4):384-398,doi: 10.1007/s12640-015-9526-z.
• Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C and Sargent A. 2015. Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.Nature. 2015; 522(7555):216-220, doi: 10.1038/nature14335. 
• Pandian V, Ramraj S, Khan FH, Azim T and Aravindan N. 2015 Metastatic neuroblastoma cancer stem cells exhibit flexible plasticity and adaptive stemness signaling. Stem Cell Research & Therapy. 2015; 6:2, doi: 10.1186/s13287-015-0002-8.