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α-Bungarotoxin, [125I]-Tyr54-, 250µCi (9.25MBq)

α-bungarotoxin, labeled with 125I on tyrosine residue 54. α-bungarotoxin is a snake venom neurotoxin that acts as an antagonist at nicotinic acetylcholine receptors (nAChRs). This product as offered at two specific activities. Specific activity indicates how much radioactivity there is per molecule of ligand. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available). This indicates that virtually every molecule of ligand provided in the stock vial is radiolabeled.

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部件号
产品尺寸
NEX126050UC
50 µCi
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NEX126250UC
250 µCi
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NEX126500UC
500 µCi
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詳情 信息

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX126:

  1. Sekiguchi, K., Imamura, S., Yamaguchi, T., Tabuchi, M., Kanno, H., Terawaki, K., Kase, Y. and Ikarashi, Y. (2011), Effects of yokukansan and donepezil on learning disturbance and aggressiveness induced by intracerebroventricular injection of amyloid β protein in mice. Phytother. Res., 25: 501–507.
  2. Paulo, J.A., Hawrot, E. (2009), Effect of homologous serotonin receptor loop substitutions on the heterologous expression in Pichia of a chimeric acetylcholine-binding protein with α-bungarotoxin-binding activity, Protein Expression and Purification, Volume 67, Issue 2, Pages 76-81.

References for NEX126H:

  1. Strack, S., Khan, M.M., Wild, F. et al. (2015), Turnover of acetylcholine receptors at the endplate revisited: novel insights into nerve-dependent behavior, J Muscle Res Cell Motil 36: 517-524.

规格

检测方法 Radiometric
新鲜的很多天 Second Monday of each month
标签位置 Nominally Labeled
分子量 7984.3
产品品牌名称 NEN Radiolabeled Ligands
放射性同位素 I-125
放射性核素 125I
受体类型 Nicotinic
运输条件 环境
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 CNS & Neurologic, Pain, Inflammation
产品尺寸 250 µCi