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Glucagon, Receptor Grade, [125I]-, 10µCi

Glucagon, labeled with 125I. This product is receptor grade, and was developed for use in receptor binding assays. Glucagon binds and activates glucagon receptor, a GPCR that is a potential drug target for diabetes, hyperplasia, and pancreatic disorders.

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部件号
产品尺寸
NEX207010UC
10 µCi
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NEX207050UC
50 µCi
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详情 信息

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX207:

  1. Bizeau, M.E. & Hazel, J.R., (2000), Membrane physical properties do not explain increased cyclic AMP production in hepatocytes from rats fed menhaden oil, Lipids, 35: 595-600.
  2. Lee, C., Hamm, M.W., (1989), Effect of Dietary Fat and Cholesterol Supplements on Glucagon Receptor Binding and Adenylate Cyclase Activity of Rat Liver Plasma Membrane, The Journal of Nutrition, 119 (4): 539–546.

规格

浓度 85.1 µCi/mL
检测方法 Radiometric
新鲜的很多天 First Monday of each month
标签位置 Nominally Labeled
分子量 3608.0
产品品牌名称 NEN Radiolabeled Ligands
放射性同位素 I-125
放射性核素 125I
受体类型 Glucagon
运输条件 环境
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 Diabetes
产品尺寸 10 µCi
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Using the NENSure Packaging System from PerkinElmer

Since 1985, the unique NENSure system has set the standard for radiochemical packaging. Based on proven performance over millions of shipments, the system provides: Ease of use, Safe storage of unused product and Reduced radiation exposure. Many NEN brand research products, including 32P-, 33P-, 35S-, 3H-, 14C- and 125I-labeled compounds, are packaged in the NENSure System, as are most radionuclides.

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