PerkinElmer
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Calcium-release activated channel CRAC / SOCE (STIM1/ORAI1)

Stable recombinant PhotoScreen® cell line expressing the CRAC / SOCE channel.

部件号 AX-013-PCL
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This product contains living cells. Some cells may be restricted for sale in specified countries. Please inquire at your local sales office for more information.

詳情 信息

PhotoScreen (Photina®) photoproteins are a kinetic luminescence technology for measuring calcium flux in cells. It is an alternative technology to fluorescent dyes being used on the FLIPR for studying GPCR targets. The large robust signal generated lets you screen for agonists, antagonists and allosteric modulators with reduced false positives.

We provide two vials of cryopreserved cells (approximately 2.5 x 106 cells/vial) with detailed product information including cell line properties, culture conditions and the pharmacological properties of the recombinant channel in functional assays (electrophysiology - whole cell voltage clamp and calcium flux luminescence assay).

All cell lines are tested for the absence of mycoplasma.

The main therapeutic interest around CRAC originates from its role in lymphocytes and mast cells, CRAC activation being a requirement for lymphocyte activation. CRAC is currently a research target for allergic disorders, autoimmune and inflammatory diseases. As Store-Operated Calcium Entry (SOCE) is a function found in all higher eukaryotic cells there are many potential therapeutic applications for CRAC regulators.

Terms and conditions apply. Some of our channels may be restricted for sale in specified countries. Please inquire at your local sales office for more information.

规格

检测目标类 Ion channel
检测目标类型 Cell line
检测验证 Calcium Luminescence
宿主细胞 HEK293
产品品牌名称 PhotoScreen
包装量 5.0 Million Cells
受体类型 CRAC
第二信使释放 Calcium flux
运输条件 干冰
产品尺寸 2 vials