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Hydroxytryptamine Creatinine Sulfate (Serotonin), 5-[1,2-3H(N)]-, 1mCi (37MBq)

5-Hydroxytryptamine Creatinine Sulfate (Serotonin, 5-HT), tritiated at the 1,2 position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors.

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部件号
产品尺寸
NET498001MC
1 mCi
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NET498005MC
5 mCi
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详情 信息

5-Hydroxytryptamine (5-HT) binds and activates 5-HT (serotonin) receptors. These receptors are a group of GPCR and ligand-gated ion channels found in the peripheral and central nervous system, and are involved in anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET498:

  1. Simmler, L. D., Anacker, A. M. J., Levin, M. H., Vaswani, N. M., Gresch, P. J., Nackenoff, A. G., Anastasio, N. C., Stutz, S. J., Cunningham, K. A., Wang, J., Zhang, B., Henry, L. K., Stewart, A., Veenstra-VanderWeele, J., and Blakely, R. D. (2017) Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine. British Journal of Pharmacology, 174: 2716–2738.
  2. Kawai, M., Goda, R., Otsuka, T., Iwamoto, A., Uotsu, N., Furuse, M., Yasuo, S. (2015) Antidepressant-like effect of bright light is potentiated by l-serine administration in a mouse model of seasonal affective disorder, Brain Research Bulletin, Volume 118: 25-33.
  3. Cui XF, Zhou WM, Yang Y, Zhou J, Li XL, Lin L, Zhang HJ. (2014) Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome. World J Gastroenterol. 20:13521–13529.

规格

浓度 1.0 - 10 mCi/mL
检测方法 Radiometric
标签位置 Nominally Labeled
分子量 387.4
产品品牌名称 NEN Radiochemicals
放射性同位素 H-3
放射性核素 3H
受体类型 5-Hydroxytryptamine
运输条件 蓝冰
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 CNS & Neurologic, Cardiovascular, Inflammation, Metabolic Disorders, Gastrointestinal
产品尺寸 1 mCi