check quantity

Ketanserin Hydrochloride (R41 468), [Ethylene-3H]-, 25µCi (925kBq)

Ketanserin hydrochloride (Sufrexal; R41468), tritiated on the ethylene group. Ketanserin is a high-affinity non-selective antagonist of 5-HT2 receptors.


25 µCi
250 µCi




详情 信息

Ketanserin is used as a radioligand for serotonin 5-HT2 serotonin receptors. Ketanserin is used clnical as an antihypertensive agent.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET791:

  1. Toshiyuki Ueki, Kazushige Mizoguchi, Takuji Yamaguchi, Akinori Nishi, Kyoji Sekiguchi, Yasushi Ikarashi, Yoshio Kase, Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice, In Journal of Ethnopharmacology, Volume 166, 2015, Pages 23-30.
  2. Lydia Schiller, Markus Donix, Monika Jähkel, Jochen Oehler, Serotonin 1A and 2A receptor densities, neurochemical and behavioural characteristics in two closely related mice strains after long-term isolation, In Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 30, Issue 3, 2006, Pages 492-503.
  3. Daniel Hoyer, Günter Engel, Hans O. Kalkman, Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (−)[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin, In European Journal of Pharmacology, Volume 118, Issues 1–2, 1985, Pages 13-23.


检测方法 Radiometric
标签位置 Specifically Labeled
分子量 431.9
产品品牌名称 NEN Radiochemicals
放射性同位素 H-3
放射性核素 3H
受体类型 5-Hydroxytryptamine
运输条件 干冰
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 CNS & Neurologic, Cardiovascular, Inflammation, Metabolic Disorders, Gastrointestinal
产品尺寸 25 µCi
  • 所有


Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.