PerkinElmer
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MBNL1 (human) LANCE Ultra TR-FRET Detection Kit, 500 assay points

The LANCE® Ultra Human MBNL1 Detection Kit is designed for detection and quantitation of human muscleblind-like protein 1 (MBNL1) in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

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For research use only. Not for use in diagnostic procedures.

部件号
产品尺寸
TRF3008C
500 Assay Points
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TRF3008M
10,000 Assay Points
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詳情 信息

The LANCE® Ultra Human MBNL1 Detection Kit is designed for detection and quantitation of human muscleblind-like protein 1 (MBNL1) in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

  • No-wash steps, no separation steps
  • TR-FRET technology
  • Sensitive detection
  • High reproducibility
  • Faster time-to-results
  • Easy automation
  • 96-well, 384-well, and 1536-well formats

LANCE® and LANCE® (Lanthanide chelate excite) Ultra are our TR-FRET (time-resolved fluorescence resonance energy transfer), homogeneous (no wash) technologies. One antibody of interest is labeled with a donor fluorophore (a LANCE Europium chelate) and the second molecule is labeled with an acceptor fluorophore (ULight dye). Upon excitation at 320 or 340 nm, energy can be transferred from the donor Europium chelate to the acceptor fluorophore if sufficiently close for FRET (~10 nm). This results in the emission of light at 665 nm.

Muscleblind-like proteins (MBNL) belong to a family of tissue-specific precursor and mature mRNA metabolism regulators in mammals. Muscleblind-like Protein 1 (MBNL1) regulates alternative splicing of pre-mRNA; it is found primarily in skeletal and cardiac muscle tissues. Increased expression of MBNL1 has been linked to myotonic dystrophy, a particular type of muscular dystrophy. The present kit permits the detection of human MBNL1 (i.e. analyte) in cell culture lysates and samples.

规格

检测目标 MBNL1
检测目标类 Protein
自动化兼容 Yes
检测方法 Time-Resolved Fluorescence (TRF), TR-FRET
产品品牌名称 LANCE Ultra
运输条件 蓝冰
Target Species Human
治疗领域 Metabolic
产品尺寸 500 Assay Points