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Neutrophil Elastase 680 FAST Fluorescent Imaging Agent

Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications. 

部件号 NEV11169
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For laboratory use only. This product is intended for animal research only and not for use in humans.

详情 信息

Neutrophil Elastase 680 FAST™ is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology) that confers an improved pharmacokinetic profile with a broader range of early imaging time points. This architecture also offers higher target specific signal with reduced background. 

Neutrophil Elastase 680 FAST is a neutrophil elastase activatable agent that is optically silent upon injection and produces fluorescent signal after cleavage by elastase produced by neutrophil cells. Neutrophil elastase is a key protease involved in acute lung injury, acute respiratory distress syndrome, as well as many other inflammatory processes such as emphysema, cystic fibrosis, COPD, wound healing, rheumatoid arthritis, ischemia-reperfusion and many others. 

Neutrophil Elastase 680 FAST fluorescent imaging agent is a selective neutrophil elastase-activatable agent designed for imaging of this serine protease both in vitro and in vivo. The half-life in plasma of Neutrophil Elastase 680 FAST is 4 hours.

规格

荧光剂类型 Activatable
光学成像分类 Fluorescence Imaging
包装量 1.0 Units
运输条件 蓝冰
治疗领域 Inflammation
产品尺寸 1 Vial (10 doses)
波长 680 nm
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技术说明

Neutrophil Elastase 680 FAST (Protocol)

Neutrophil Elastase 680 FAST activatable fluorescent imaging agent Protocol

PDF 257 KB
Neutrophil Elastase 680 FAST™ (Data Sheet)

Neutrophil Elastase 680 FAST™ is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology) that confers an improved pharmacokinetic profile with a broader range of early imaging time points. This architecture also offers higher target specific signal with reduced background.

PDF 68 KB

海报

A novel NIR dye for in vivo temporal tracking of labeled macrophages to sites of acute inflammation

A novel NIR dye for in vivo temporal tracking of labeled macrophages to sites of acute inflammation

PDF 689 KB
Non-Invasive Quantitative Tomography of Disease Progression and Therapeutic Response

We have demonstrated the ability of our Fluorescence Tomography (FMT 2500) in vivo imaging system and ProSense 680 to non-invasively visualize and quantify inflammation in the lung in a robust and validated manner. The consistency of the quantitative tomography, as well as its excellent correlation with BAL assessment of eosinophilia, provide a powerful toolkit for quantifying the therapeutic efficacy of dexamethasone treatment. Utilizing new and existing imaging agents, FMT imaging in asthma research provides useful, non-invasive tools for understanding pulmonary inflammation and for developing new therapeutics in vivo.

PDF 581 KB