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Norepinephrine, Levo-[ring-2,5,6-3H]-, 1mCi (37MBq)

Levo-Norepinephrine, tritiated on the ring group. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET).

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部件号
产品尺寸
NET678250UC
250 µCi
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NET678001MC
1 mCi
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NET678005MC
5 mCi
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详情 信息

Norepinephrine (NA) is a neurotransmitter and hormone that increases heart rate and blood pressure, and is involved in the fight-or-flight response. It is widely used to treat low blood pressure.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET678:

  1. Auch-Schwelk, W., Starke, K. and Steppeler, A. (1983), Experimental conditions required for the enhancement by α-adrenoceptor antagonists of noradrenaline release in the rabbit ear artery. British Journal of Pharmacology, 78: 543–551.
  2. Bryan-Lluka, L., Siebert, G. & Pond, S. (1999) Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells. Naunyn-Schmiedeberg's Arch Pharmacol, 360: 109.

规格

浓度 1.0 - 10 mCi/mL
检测方法 Radiometric
标签位置 Specifically Labeled
分子量 169.2
产品品牌名称 NEN Radiochemicals
放射性同位素 H-3
放射性核素 3H
受体类型 Adrenoceptors
运输条件 干冰
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 CNS & Neurologic, Cardiovascular, Metabolic Disorders
产品尺寸 1 mCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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