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Orexin A, [125I]-, 50µCi (1.85MBq)

Orexin A, labeled with 125I. Orexin A binds to orexin receptors (OX1 and OX2), which are potential drug targets for sleep disorders.

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部件号
产品尺寸
NEX367010UC
10 µCi
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NEX367050UC
50 µCi
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詳情 信息

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX367:

  1. Wieland, H. A., Söll, R. M., Doods, H. N., Stenkamp, D., Hurnaus, R., Lämmle, B. and Beck-Sickinger, A. G. (2002), The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor. European Journal of Biochemistry, 269: 1128–1135.

规格

检测方法 Radiometric
新鲜的很多天 Second Monday of each month
标签位置 Nominally Labeled
产品品牌名称 NEN Radiolabeled Ligands
放射性同位素 I-125
放射性核素 125I
受体类型 Orexin
运输条件 干冰
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 Metabolic Disorders, Gastrointestinal
产品尺寸 50 µCi