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Pancreatic Polypeptide (human), [125I], 10µCi

Human pancreatic polypeptide (PP), labeled with 125I. Pancreatic polypeptide acts as an agonist at Pancreatic polypeptide receptors (Neuropeptide Y receptors), a class of GPCRs involved in appetite, circadian rhythm, and anxiety.

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部件号 产品尺寸
NEX315010UC 10 µCi
NEX315050UC 50 µCi
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概览

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX315:

  1. Sejling, AS., Lange, K.H.W., Frandsen, C.S. et al. (2015), Infrared thermographic assessment of changes in skin temperature during hypoglycaemia in patients with type 1 diabetes, Diabetologia 58: 1898-1906.
  2. Dirksen, C., Jørgensen, N.B., Bojsen-Møller, K.N., Kielgast, U., Jacobsen, S.H., Clausen, T.R., Worm, D., Hartmann, B., Rehfeld, J.F., Damgaard, M., Madsen, J.L., Madsbad, S., Holst, J.J., Hansen, D.L. (2013), Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass. Int J Obes, 37 (11): 1452-1459.

规格

检测方法 Radiometric
新鲜的很多天 Fourth Monday of each month
标签位置 Nominally Labeled
分子量 4179.0
产品品牌名称 NEN Radiolabeled Ligands
放射性同位素 I-125
放射性核素 125I
受体类型 Neuropeptide Y
运输条件 环境
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 CNS & Neurologic, Metabolic Disorders, Gastrointestinal
产品尺寸 10 µCi

资源,活动及更多信息

资源类型 文件名 文件格式
技术说明 Low Volume Handling Suggestions for Iodine-125 Labeled Compounds PDF  177 KB
单页 Using the NENSure Packaging System from PerkinElmer PDF  447 KB