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Prazosin, [7-Methoxy-3H]-, 1mCi (37MBq)

Prazosin, tritiated at the 7-methoxy position. Prazosin acts as an inverse agonist at the α1-adrenergic receptor.

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部件号
产品尺寸
NET823025UC
25 µCi
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NET823250UC
250 µCi
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NET823001MC
1 mCi
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详情 信息

Prazosin is an α1-blocker, and is used to treat high blood pressure, anxiety, and post-traumatic stress disorder. It binds the α1-adrenergic receptor, a GPCR that plays a role in vasconstriction and appetite suppression.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET823:

  1. Oshita, M., Kigoshi, S. and Muramatsu, I. (1991), Three distinct binding sites for [3H]-prazosin in the rat cerebral cortex. British Journal of Pharmacology, 104: 961–965.
  2. Hanft, G., Gross, G., Beckeringh, J. J. and Korstanje, C. (1989), α1-Adrenoceptors: the ability of various agonists and antagonists to discriminate between two distinct [3H]prazosin binding sites. Journal of Pharmacy and Pharmacology, 41: 714–716.

规格

浓度 1.0 - 10 mCi/mL
检测方法 Radiometric
标签位置 Specifically Labeled
分子量 382.4
产品品牌名称 NEN Radiochemicals
放射性同位素 H-3
放射性核素 3H
受体类型 Adrenoceptors
运输条件 干冰
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 CNS & Neurologic, Cardiovascular, Metabolic Disorders
产品尺寸 1 mCi