Prazosin, tritiated at the 7-methoxy position. Prazosin acts as an inverse agonist at the α1-adrenergic receptor.
Prazosin is an α1-blocker, and is used to treat high blood pressure, anxiety, and post-traumatic stress disorder. It binds the α1-adrenergic receptor, a GPCR that plays a role in vasconstriction and appetite suppression.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET823:
|特殊订购信息||This is a radioactive product - shipping address must have a license to receive radioactive materials.|
|治疗领域||CNS & Neurologic, Cardiovascular, Metabolic Disorders|