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Sphingosine, [3-3H]-, D-erythro>97%, 50µCi (1.85MBq)

50 µCi quantities of tritiated sphingosine are available for your research.

部件号 NET1072050UC
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详情 信息

Sphingosine is component of sphingolipids, a class of cell membrane lipis and phospholipids. Sphingosine can be phosphorylated by sphingosine kinase type 1 and sphingosine kinase type 2, producing sphigosine-1-phosphate. References:

  1. Ikeda, H. et al. Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. Gastroenterology 124, 459–469 (2003).
  2. Goldkorn, T. et al. Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action. J. Biol. Chem. 266, 16092–16097 (1991).
  3. Wang, E., Norred, W. P., Bacon, C. W., Riley, R. T. & Merrill, A. H. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J. Biol. Chem. 266, 14486–14490 (1991).
  4. Olivera, A. et al. Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation. J. Biol. Chem. 269, 17924–17930 (1994).

规格

浓度 <1.0 mCi/mL
检测方法 Radiometric
标签位置 Specifically Labeled
分子量 299.48
产品品牌名称 NEN Radiochemicals
放射性同位素 H-3
放射性核素 3H
运输条件 干冰
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 CNS & Neurologic
产品尺寸 50 µCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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