PerkinElmer
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LANCE Ultra ULight™-anti-6xHis, 1 nmole

Mouse monoclonal anti-polyHistidine tag antibody labeled with ULight™ dye.

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TRF0105-D
1 nmol
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TRF0105-M
10 nmol
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TRF0105-R
100 nmol
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详情 信息

The versatility of LANCE TR-FRET technology allows the assembly of donor and acceptor dye pairs for use in protein binding and other assays. Choose your preferred donor- and acceptor-labeled reagents to design your own assay. This is assay design at its most flexible; featuring the most common affinity biomolecules and europium chelate-labeling reagents. LANCE toolbox reagents can be used to design a variety of assays, including kinase, protein-protein interaction, protein-nucleic acid interaction, protein-small molecule interaction, epigenetic, receptor-ligand binding, nuclear receptor, receptor dimerization, ubiquitination and other post-translational modifications, protease, and other binding and enzymatic assays.

规格

抗体偶联物 Anti-6X His
自动化兼容 Yes
检测方法 Time-Resolved Fluorescence (TRF), TR-FRET
实验类型 In vitro
荧光基团 ULight
产品品牌名称 LANCE Ultra
运输条件 干冰
产品尺寸 1 nmol
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应用文献

Comparison of LANCE Ultra TR-FRET to PerkinElmer's Classical LANCE TR-FRET Platform for Kinase Applications

Protein kinases play a major role in normal cellular functions such as cell proliferation, angiogenesis, and cell adhesion. Dysregulation of kinase activity has been shown to be associated with several human diseases including cancer, diabetes and morphological disorders. This makes kinases crucial targets for the discovery and development of new drugs.

PDF 805 KB
Development and Optimization of Kinase Assays using New LANCE Ultra TR-FRET Reagents

Dysregulation of kinase activity has been shown to be associated with several human diseases including cancer, diabetes and morphological disorders. Because of their function, kinases are crucial targets for drug discovery. Analysis of the human genomehas revealed the existence ofnearly 520 genes encoding kinases.

PDF 583 KB

海报

Comparison of LANCE Ultra with Other TR-FRET Platforms

Protein kinases play a major role in normal cellular functions such as cell proliferation, angiogenesis, and cell adhesion. Dysregulation of kinase activity has been shown to be associated with several human diseases including cancer, diabetes and morphological disorders. This makes kinases crucial targets for drug discovery. Analysis of the human genome has revealed the existence of nearly 520 genes encoding kinases.

PDF 356 KB
Development, Automation and Miniaturization of High-Throughput Serine/Threonine Kinase Assays Using the LANCE® Ultra Platform

Protein kinases are involved in the regulation of many aspects of the cellcycle, including proliferation, differentiation, secretion and apoptosis. Aberrant protein kinase expression or functioning is a cause orconsequence of many human diseases. As a result, kinases have become extremely popular for drug discovery programs and this has prompted the development of many kinase assay technologies suitable for highthrough putscreening (HTS).

PDF 364 KB
Novel Substrates for Fluorescence-based Protein Tyrosine Kinase Assays

Protein tyrosine kinases (PTK) are involved in the regulation of many aspects of the cell cycle, including proliferation, differentiation, secretion and apoptosis. Aberrant protein kinase expression or function is a cause or consequence of many human diseases like cancer and atherosclerosis. As a result, kinases became very important targets in drug discovery.

PDF 276 KB
Poster LANCE Ultra Tyrosine kinases

Of the 518 known human kinases, 90 are tyrosine (Tyr) kinases. Protein Tyr kinases play a key role in signal transduction and normal cell growth. They are also involved in numerous proliferative diseases like cancer and atherosclerosis, in addition to a number of autoimmune diseases. For these reasons, Tyr kinases are often targets for new drug discovery in many laboratories involved in basic R&D, disease and therapeutics research, and HTS.

PDF 276 KB