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Staphylococcus aureus - Xen8.1

Staphylococcus aureus - Xen8.1 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from the parental strain 8325-4. Staph. aureus-Xen8.1 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.

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部件号
119239
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概览

Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVIS® imaging technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research. PerkinElmer's bioluminescent infectious disease light-producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers.

  • Engineered Bacterium: Staphylococcus aureus - Xen8.1
  • Parental Strain: 8325-4
  • In Vitro/Ex Vivo: Growth profiles, Catheter model
  • In Vivo: Sepsis, Soft tissue, Pouch, Pneumonia, Biofilm models

Advantages of using bioluminescent light-producing microorganisms for drug discovery in vitro:

  • Rapid and readily amenable to high throughput screening, e.g., 96 or 384-well format
  • Sensitivity - subtle changes in cellular viability are rapidly detected
  • Inexpensive - no additional substrates needed for bacterial assays

Advantages of using bioluminescent light-producing microorganisms for drug discovery in vivo:

  • Rapid identification of lead drug candidates
  • Real-time efficacy data
  • May help to decrease drug failure by allowing disease relapse to be monitored in the same animal

免责声明:  For laboratory use only. This product is intended for animal research only and not for use in humans.

规格

革兰氏阳性革兰氏阴性 Gram positive
荧光素酶分类 Bacterial luciferase
光学成像分类 Bioluminescence Imaging
产品品牌名称 XenoLight
运输条件 环境
治疗领域 Bacterial infection
产品尺寸 1 agar plate

工具

资源,活动及更多信息

资源类型 文件名 文件格式
技术说明 Bacterial Growth Preparation PDF  26 KB
产品手册 In Vivo Imaging Agents Brochure PDF  2 MB
Citations Library View peer reviewed publications using PerkinElmer's In Vivo Imaging Reagents 链接
网络研讨会 View our complete list of in vivo webinars available on demand 链接