The journey to discovering novel targets starts with building a deep understanding of the underlying biology. To achieve this, researchers are increasingly looking to 3D cell cultures, microtissues, and organoids to bridge the gap between 2D cell cultures and in vivo animal models. 3D models provide more physiologically relevant conditions than biochemical assays and 2D cell cultures, as they more closely mimic the microenvironment, cell-to-cell interactions, and biological processes that occur in vivo. Plus, they show a higher degree of morphological and functional differentiation.
PerkinElmer takes a solutions-based approach to support customers at every step of the cell culture workflow, from seeding and sample processing to readout and analysis. With our best-in-class instruments, reagents, and informatics-based solutions you can grow, detect, and analyze 3D cell cultures at scale and begin generating more physiologically relevant data to better understand biological processes and make informed decisions.
For research use only. Not for use in diagnostic procedures.
The first critical step in your 3D cell culture workflow is seeding, using specific methods and growth conditions. Methods are selected depending on the biological question, complexity of the model, and readout technology. Starting with the right cell model, that first needs to be characterized, cells can be grown as single spheroids in an ultra-low attachement (ULA) plate or cultured in hydrogels. Both methods are scalable using liquid handling.
Choosing the right microplate is a critical, often overlooked, part of an assay. The right microplate helps provides valuable data, whereas the wrong microplate can lead to missed or inaccurate data leading to missed project timelines and ultimately higher costs. New technologies for drug developmen ...
How to use Growdex hydrogels We offer a range of products for scalable animal-free 3D cell culture applications, providing convenience and consistent results. GrowDex® hydrogels are natural nanofibers of cellulose extracted from wood and sourced from sustainable and responsibly managed forests. Supp ...
The JANUS® G3 automated liquid handling workstations offer flexible automated sample preparation solutions to meet your specific application needs. The JANUS G3 portfolio includes both dedicated, application-specific workstations and personalized automated solutions. The JANUS G3 workstation can be ...
Horizon offers a catalogue of more than 3000 off-the-shelf edited cell lines and a variety of gene-modulation reagents. In particular, Horizon’s Edit-R™ All-in-one system and Accell siRNA reagents have been proven to work well with 3D cell models.
Nexcelom offers a broad range of brightfield, fluorescent, or plate-based automated cell counters that can generate consistent counting results.
3D cell models usually need to grow for days, or even weeks, before they are ready for read-out. Monitoring that growth and proliferation over this long period of time is critical to preserving your samples so they can progress to imaging readout. Our live-cell imaging systems help to significantly reduce the time and effort needed to quantify key aspects including size, number, growth, or shape. Plus, with our line of innovative reagents, you’ll have the right solutions available to prepare your 3D sample for any readout ― imaging, detection and sequencing.
PerkinElmer的创新微流体技术可实现高重现性、高分辨率的电泳分离。无论是为了获得更好的基因表达数据而进行的RNA完整性分析，还是重测序应用中评估PCR片段，LabChip GX Touch HT都能加速您的研究并帮助您更快地生成更有意义的数据。
MuviCyte活细胞成像系统设计用于细胞培养箱内，使细胞能够维持在最佳条件下并且广泛适配各种培养容器。 生命科学研究实验室研究细胞行为和通路从而更深入地理解功能、疾病机制和对治疗的反应。活细胞成像是从珍贵的细胞样本中获取最大信息的重要工具。 MuviCyte活细胞成像系统由MuviCyte活细胞成像仪加上4x、10x和20x物镜、图像工作站以及显示器组成。
Drug discovery is a complex, costly, and time-consuming undertaking. And for research scientists, high-throughput screening is where the journey to discovery begins. Your job is to move from target to hit to candidate quickly and efficiently – with as little wasted resources as possible. Our HTS scr ...
用常规方法进行蛋白和核酸的准确定量分析是比较困难的。我们的TSA试剂盒可以大幅提升免疫组化、免疫荧光和原位杂交的信号强度，并且对检测设备无特殊要求。 我们也可以在单张图像上实现七色（含DAPI）复染的多标记蛋白检测。其工作流程与标准的免疫组化方案类似，而且不必担心抗体物种来源造成的交叉干扰，全部选用效率最高的抗体完成多色标记。常见的标记例如CD20, CD4, CD45RO, CD68, FOXP3, panCK等等。 仅限于科研使用，不用于临床诊断。
Celigo is a plate-based benchtop brightfield and fluorescent imaging system designed for whole-well live-cell analysis and cell sample characterization. Celigo images and analyzes cells in various types of vessels without disturbing their natural state.
Developed by Honeycomb Biotechnologies, the HIVE™ scRNAseq Solution integrates sample storage and single-cell profiling into a complete workflow, solving the issues that limit single-cell RNA analysis.
Selecting the right method for measuring the biological response of 3D models depends on the question asked and the specifics of the model system used. Whether you’re repeatedly monitoring microtissue size using brightfield imaging or measuring sensitive detection of secreted proteins, each readout type poses unique challenges that can be overcome with the right tools. Our line of sensitive, yet powerful microplate readers and high-content analysis systems, plus innovative reagents, is designed for 3D cell culture detection, and together with our specially designed microplates, can help shed more light on to your sample.
我们提供适合任何实验室各种应用需求的多模式微孔板读板仪。每一款读板仪都具有业内领先的检测技术，因此无论您选择任何一款仪器，您都可获得针对您应用的最佳检测性能。 VICTOR X 微孔板读板仪 市场上第一台多功能微孔板读板仪，VICTOR™ X 系列具有多种检测功能，性能可靠，为各种规模的实验室提供集灵活性、高速度和高性能于一体的解决方案。 EnSpire 微孔板读板仪 第一台整合了Corning® Epic® 无标记技术的桌面式多功能读板仪，EnSpire® 专为多用户科研环境设计，提供高性能检测技术，且在保证灵敏度的前提下进行各种灵活的实验应用。 EnSight 微孔板读板仪 第一台整合了多 ...
High-Content Analysis (HCA) or High-Content Screening (HCS) combines high-throughput automated imaging and analysis to extract quantitative multi-parametric data at the single-cell level. Originally developed as a complementary technology to traditional biochemical high-throughput screening (HTS) in ...
It’s not easy to extract information from 3D datasets – readouts and large amounts of data need to be analyzed, and in context. Our scientific software and informatics solutions give you the tools to optimize imaging of 3D cell models and then aggregate, search, mine, and visualize critical data, and turn it into actionable insights.
Easily quantify complex cellular phenotypes with Harmony® high-content analysis software. Harmony software is designed for PerkinElmer high-content screening systems.
Signals Image Artist™ is our next generation image analysis and management platform for high-content screening and cell imaging data. Quickly process, analyze, share, and store the vast volumes of data generated by high-content screening and cellular imaging, including live cell imaging, 3D imaging, ...
Signals VitroVivo is an intuitive, configurable, flexible screening workflow processor coupled with the unparalleled data visualization and analysis capabilities of TIBCO Spotfire.