PerkinElmer

生物制剂

Biological products, such as therapeutic proteins, monoclonal antibodies, vaccines, and cell and gene therapy products have become increasingly important. Unlike traditional chemically synthesized drugs that act on a hydrophobic pocket of a protein to activate or inhibit a kinase pathway, biotherapeutics pharmacological action is via binding to its target or immunomodulation.

Due to the complex nature of biological products, scientists encounter multiple challenges from early drug discovery through development. For example, during identification of a clone with the desired immunogenicity that can demonstrate binding specificity to the target and subsequent modulation or elicit the desired immune response, and further during clone characterization, scale-up, and production of these products.

From discovery through manufacturing, harnessing large molecule drugs to create safe and effective therapies is complex and expensive. PerkinElmer enables scientists to develop and streamline their entire biologics workflow so they can overcome these challenges and bring consistent, high-quality, biological medicines to market faster.

Biomolecular Discovery

During the early stages of drug discovery, it is critical to understand the target biology, mechanism of action (MoA) using the most accurate instrumentation including automation, and software to simplify complex workflows from clone selection and expression to lead discovery and screening.

Accelerate your biomolecular discovery by using a combination of in vitro and in vivo techniques accoupled with powerful software transforming data into insights.

  • Cellular imaging for in vitro target validation
  • In vivo imaging for target discovery
  • Highly interactive visualization that facilitates the rapid isolation of compounds based on key criteria for further analysis
  • In silico

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Immune Function

Comprehending the interactions between innate and adaptive immunity play a critical role in the research, discovery and the development of biological products.

Due to the complexity of the immune system and its mechanisms, scientists rely on the latest advancements in technology including immune functional assays to better understand the immune system.

  • Assess cytotoxicity
  • Cytokine release and cell signalling
  • Cellular response

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Biologics Characterization

Biological products characterization ensures stability of the drug across the entire process, in terms of the structure, specific activity against the target and maintenance of the functional attributes as defined by Critical Quality Attributes (CQA's) that must be met to comply with regulatory guidelines.

From early drug discovery characterization, scientists use developability approaches to mitigate risk in late drug development during Chemistry, Manufacturing and Control (CMC) testing by relying on analytical instrumentation including GxP compliance and instrument qualification to guarantee safe and effective drug products used in clinical trials and reduce time to market.

  • Identity
  • Potency
  • Purity and impurity profile
  • Stability testing

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Safety & Efficacy

During early and late drug development a comprehensive set of studies are required to guarantee biological products are safe and effective, uncovering any potential risks to patients.

Preclinical development including small animal model testing is required to identify side effects such as immunotoxicity of the large molecule candidate on the immune system.

Strict regulations such as GLP, GMP and GCP are in place to minimize risks, guarantee safety and accelerate the process of a biological product approval.

  • Immunogenicity
  • Pharmacology and toxicology studies
  • Clinical trials

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Manufacturing of Biologics

When it comes to drug manufacturing we offer everything to stay compliant each step of the way, from our robust characterization technologies such as microfluidics and spectroscopy platforms to supporting the evaluation of viral therapeutics, including vaccines, repurposed drugs during the Chemistry Manufacturing and Controls (CMC) protocols and QA/QC batch release of commercially available medicines.

  • Drug substance and excipients
  • Drug product
  • Control of impurities
  • Regulatory and compliance including 21 CFR Part 11 software

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Explore Our Biologics Solutions

Drug Repurposing

Drug repurposing or drug repositioning is a well-known approach used by scientists to minimize the costs and mitigate risks associated with drug development pro ...

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传染病

Detect disease-causing microbes, and detect and quantitate biomarkers of infectious disease, with our wide range of in vivo, in situ, cellular, and biochemical ...

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CMC Testing

The Chemistry, manufacturing, and control (CMC) testing of drug substances and drug products play a critical role guaranteeing the quality of the drug product e ...

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Drug Manufacturing QA/QC

When it comes to QA/QC, we offer everything to stay compliant each step of the way, from our analytical instrumentation to our unique OneSource service and supp ...

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应用基因组学

PerkinElmer’s optimized, automated solutions are designed to improve the efficiency of your genomic workflows. These solutions are designed to eliminate the cha ...

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药物研发试剂

Drug discovery is a complex, costly, and time-consuming undertaking. And for research scientists, high-throughput screening is where the journey to discovery be ...

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临床前体内成像解决方案

小动物活体成像完整解决方案 我们的成像设备及试剂正在帮助全球的科学家进行包括癌症、感染性疾病、心血管疾病、炎症与免疫疾病、药物研发等各领域的研究。 利用我们的三维多模式成像设备,您既可获取活体动物体内的功能性影像数据,又可获取其结构性影像数据。 利用我们的开放式荧光手术导航系统,您可以更准确地确定肿瘤组织及正常组织,并 ...

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Explore Our Instrument Solutions

液体处理程序

利用我们简单易用的自动化液体处理解决方案加速您的生命科学研究:从工作台到诊所。 由基因组学、生物治疗学、高通量筛查、以及高含量分析领域大量经过验证的科学专业知识进行设计并作为支持,我们的各种可适应性液体处理平台和它们推动的科学研究一样具有动态性。我们的下一代测序自动化液体处理文库制备解决方案通过现今的测序技术消除了处理 ...

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高内涵筛选与分析

High-Content Analysis (HCA) or High-Content Screening (HCS) combines high-throughput automated imaging and analysis to extract quantitative multi-parametric dat ...

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Microfluidic Protein Characterization Analysis

Microfluidic Electrophoresis Analysis Proteins differ from each other in their size, molecular structure and physiochemical properties. These differences allow ...

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多功能酶标仪

我们提供适合任何实验室各种应用需求的多模式微孔板读板仪。每一款读板仪都具有业内领先的检测技术,因此无论您选择任何一款仪器,您都可获得针对您应用的最佳检测性能。 VICTOR X 微孔板读板仪 市场上第一台多功能微孔板读板仪,VICTOR™ X 系列具有多种检测功能,性能可靠,为各种规模的实验室提供集灵活性、高速度和高性 ...

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原子光谱

如果您正在寻找世界领先的AA,ICP-OES,ICP-MS或汞分析系统,您已经到了正确的地方。 全世界数以万计的用户依靠PerkinElmer光谱仪快速、高效、轻松地从无机元素分析中获得准确的结果。无论哪种领域、应用或样品类型,我们都有相应的工具和专业知识可提供帮助 - 所有这些都是基于50多年来在原子光谱领域累积的前 ...

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分子光谱

复杂材料表征技术,总有一款适合您。我们拥有全面的分析解决方案,可以为各种的实验室提供理想的分子光谱仪器,包括紫外光谱,红外光谱及荧光光谱。 更高精度,确保获得更高的灵敏度 灵活的设计,满足不同尺寸的样品测试 多种采样附件可供选择 更短的样品配置时间 软件易学易用,提供专业的结果 作为红外光谱技术的业界先驱,我们在60年 ...

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热分析

使用我们全面的热分析仪器系列,提高热分析的精确度,灵敏度和性能。我们业界领先技术的应用包括: QA/QC应用 药物过程研究 聚合物研究 回收塑料的识别 包装材料的测定 纳米材料 涂料 复合材料 其他更多 仅供科学研究,非临床诊断用途。

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色谱

无论您要面对怎样的的应用、技术和法规要求,我们都有色谱解决方案来解决您的分离和检测难题。 我们的多元化产品组合包括液相色谱仪(LC),液相色谱/质谱联用仪(LC/MS),气相色谱仪(GC),气相色谱/质谱联用仪(GC/MS)和Arnel-GC工程色谱系统。此外,我们提供最全面的样品前处理技术解决方案,其中包括一系列的自 ...

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