Biological products, such as therapeutic proteins, monoclonal antibodies, vaccines, and cell and gene therapy products have become increasingly important. Unlike traditional chemically synthesized drugs that act on a hydrophobic pocket of a protein to activate or inhibit a kinase pathway, biotherapeutics pharmacological action is via binding to its target or immunomodulation.

Due to the complex nature of biological products, scientists encounter multiple challenges from early drug discovery through development. For example, during identification of a clone with the desired immunogenicity that can demonstrate binding specificity to the target and subsequent modulation or elicit the desired immune response, and further during clone characterization, scale-up, and production of these products.

From discovery through manufacturing, harnessing large molecule drugs to create safe and effective therapies is complex and expensive. PerkinElmer enables scientists to develop and streamline their entire biologics workflow so they can overcome these challenges and bring consistent, high-quality, biological medicines to market faster.

Biomolecular Discovery

During the early stages of drug discovery, it is critical to understand the target biology, mechanism of action (MoA) using the most accurate instrumentation including automation, and software to simplify complex workflows from clone selection and expression to lead discovery and screening.

Accelerate your biomolecular discovery by using a combination of in vitro and in vivo techniques accoupled with powerful software transforming data into insights.

  • Cellular imaging for in vitro target validation
  • In vivo imaging for target discovery
  • Highly interactive visualization that facilitates the rapid isolation of compounds based on key criteria for further analysis
  • In silico

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Immune Function

Comprehending the interactions between innate and adaptive immunity play a critical role in the research, discovery and the development of biological products.

Due to the complexity of the immune system and its mechanisms, scientists rely on the latest advancements in technology including immune functional assays to better understand the immune system.

  • Assess cytotoxicity
  • Cytokine release and cell signalling
  • Cellular response

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Biologics Characterization

Biological products characterization ensures stability of the drug across the entire process, in terms of the structure, specific activity against the target and maintenance of the functional attributes as defined by Critical Quality Attributes (CQA's) that must be met to comply with regulatory guidelines.

From early drug discovery characterization, scientists use developability approaches to mitigate risk in late drug development during Chemistry, Manufacturing and Control (CMC) testing by relying on analytical instrumentation including GxP compliance and instrument qualification to guarantee safe and effective drug products used in clinical trials and reduce time to market.

  • Identity
  • Potency
  • Purity and impurity profile
  • Stability testing

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Safety & Efficacy

During early and late drug development a comprehensive set of studies are required to guarantee biological products are safe and effective, uncovering any potential risks to patients.

Preclinical development including small animal model testing is required to identify side effects such as immunotoxicity of the large molecule candidate on the immune system.

Strict regulations such as GLP, GMP and GCP are in place to minimize risks, guarantee safety and accelerate the process of a biological product approval.

  • Immunogenicity
  • Pharmacology and toxicology studies
  • Clinical trials

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Manufacturing of Biologics

When it comes to drug manufacturing we offer everything to stay compliant each step of the way, from our robust characterization technologies such as microfluidics and spectroscopy platforms to supporting the evaluation of viral therapeutics, including vaccines, repurposed drugs during the Chemistry Manufacturing and Controls (CMC) protocols and QA/QC batch release of commercially available medicines.

  • Drug substance and excipients
  • Drug product
  • Control of impurities
  • Regulatory and compliance including 21 CFR Part 11 software

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Explore Our Biologics Solutions

Drug Repurposing

Drug repurposing or drug repositioning is a well-known approach used by scientists to minimize the costs and mitigate risks associated with drug development pro ...

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Viral Research Solutions

The discovery of antivirals and vaccines has revolutionized medicine and saved billions of children from diseases such as polio and smallpox. However, high muta ...

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CMC Testing

The Chemistry, manufacturing, and control (CMC) testing of drug substances and drug products play a critical role guaranteeing the quality of the drug product e ...

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Pharmaceuticals QA/QC

When it comes to QA/QC, we offer everything to stay compliant each step of the way, from our analytical instrumentation to our unique OneSource service and supp ...

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PerkinElmer’s optimized, automated solutions are designed to improve the efficiency of your genomic workflows. These solutions are designed to eliminate the cha ...

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Drug Discovery Reagents

Drug discovery starts with an understanding of the basics of diseases and disease pathways. Throughout the process of unraveling the complexity of disease pathw ...

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In Vivo Preclinical Imaging Solutions

Tracking, monitoring, and visualizing biological processes and disease progression is key to not only helping you better understand biology but also crucial in ...

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Explore Our Instrument Solutions

Liquid Handlers

PerkinElmer has been providing liquid handling solutions for over 40 years. A pioneer and innovator in this industry, we offer a comprehensive lineup of robotic ...

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High Content Screening Instruments

High-Content Analysis (HCA) or High-Content Screening (HCS) combines high-throughput automated imaging and analysis to extract quantitative multi-parametric dat ...

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Microfluidic Protein Characterization Analysis

Microfluidic Electrophoresis Analysis Proteins differ from each other in their size, molecular structure and physiochemical properties. These differences allow ...

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Microplate Readers

As many of you know, microplate readers are instruments used to detect biological, chemical, biochemical or physical events from samples in a microplate. This i ...

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Atomic Spectroscopy

If you're looking for proven AA, ICP-OES, ICP-MS, or mercury analysis systems, you've come to the right place. PerkinElmer has been at the forefront of atomic s ...

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Molecular Spectroscopy

Today’s advanced and increasingly diverse Advanced Materials laboratories are facing new challenges daily – starting from raw materials right up to the finished ...

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Thermal Analysis

Improve accuracy, sensitivity, and performance using our comprehensive portfolio of instruments in Differential Scanning Calorimetry (DSC), Thermogravimetric An ...

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Whatever your application, industry requirements or regulations, we have a breadth of solutions designed to solve your separation and detection challenges. Our ...

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