Drug discovery is a complex, costly, and time-consuming undertaking. And for research scientists, high-throughput screening is where the journey to discovery begins.

Your job is to move from target to hit to candidate quickly and efficiently – with as little wasted resources as possible. Our HTS screening reagents do just that, providing you with a wide range of validated reagents and kits in Alpha, LANCE®, DELFIA®, and other assay technologies.

Accelerate your workflow, while getting consistent, accurate, and physiologically relevant results.


Alpha Technology

Alpha is a homogeneous, bead-based assay platform offering several advantages over traditional ELISAs. This versatile, easy-to-use platform is suitable for a wide range of applications.

AlphaLISA®, AlphaLISA SureFire® Ultra, Alpha Screen®, AlphaPlex®, and Alpha kits and standalone reagents can be used to detect:

  • Proteins and phosphoproteins
  • Protein: protein interactions – both high and low affinity
  • Receptor-ligand interactions
  • DNA interactions
  • Post-translational protein modifications



TR-FRET Technology

TR-FRET combines the benefits of Time Resolved Fluorescence (TRF) with those of Forster Resonance Energy Transfer (FRET). PerkinElmer offers two TR-FRET technologies - HTRF® (Homogeneous Time Resolved Technology) and LANCE® (Lanthanide Chelate Excite) Ultra TR-FRET.

HTRF and LANCE Ultra kits and standalone reagents can be used to detect:

  • Proteins and phosphoproteins
  • Protein: protein interactions
  • Receptor-ligand interactions
  • Second messenger levels



TRF Technology

DELFIA® (Dissociation-Enhanced Lanthanide Fluorescence Immunoassay) is a washed based, time-resolved fluorescence (TRF) detection platform that utilizes fluorescent lanthanide chelates rather than other fluorophores. While superficially quite similar to an ELISA, DELFIA® comes with additional benefits. DELFIA® has a stable, time-resolved fluorescent signal which improves the assay dynamic range.

DELFIA® kits and standalone reagents can be used to detect:

  • Proteins and phosphoproteins
  • Protein: protein interactions
  • Cytotoxicity
  • Cell proliferation



Luminescence Assays

Luminescence assays are used throughout the drug discovery workflow. Our assays are provided a simple, easy-to-use microplate format.

Our luminescence assays include:

  • Reporter gene assays
  • Cytotoxicity and cell proliferation assays
  • Kinase activity assays


Receptor Cell Lines & Membranes

Receptor Cell Lines & Membranes

Whether you are working with cell-based or biochemical assays, our GPCR overexpressing cell lines and membranes originate from clones carefully selected to produce the most effective assays.

Our cell line clones have been selected to produce the most effective:

  • Radioligand binding
  • GTP binding
  • cAMP activation
  • Calcium flux
  • Downstream phosphorylation measurements



Radiometric Assays

Radiometric detection remains the most sensitive assay today. We offer scintillation proximity assays (SPAs) and radiolabeled ligands for ligand binding studies, plus a vast array of radiochemicals for all your research needs.

Our products support a range of radiometric assays, including:

  • Scintillation Proximity Assays (SPA)
  • Receptor-Ligand binding assays – using either tritiated and iodinated compounds


Study Target Engagement with CETSA®

The Cellular Thermal Shift Assay (CETSA®) is a unique tool allowing the study of the interaction of ligands with their intended target biomolecules. Particularly relevant in the context of early-stage drug discovery, CETSA® can be combined with proximity-based assays such as Alpha or HTRF, offering distinct advantages to existing techniques that require cloning or purified protein to work.

Alpha- or HTRF-CETSA®:

  • Is a cell-based, physiologically relevant target engagement study tool
  • Uses endogenous protein levels in unmodified or even primary cells
  • Can be applied throughout the drug discovery workflow in a reliable, high-throughput format


Newest Assays

PerkinElmer R&D scientists focus on developing fully validated, ready-to-use kits and reagents for the hottest new targets. We continue to evolve our product offering as your science evolves.

Our Alpha, HTRF®, LANCE® Ultra TR-FRET, and DELFIA® TRF technologies offer alternatives to standard ELISA assays, each with a larger dynamic range and higher signal-to-noise ratio. Alpha, HTRF and LANCE Ultra TR-FRET have the added advantage of having no wash or separation steps, saving you valuable time.



PerkinElmer offers a range of ELISA alternative immunoassay technologies that enable selection of the optimal immunoassay platform for your requirements. From sample compatibility to sample volume, throughput, detectable range, signal window, signal stability, reproducibility, automation compatibility, and desired speed of results, PerkinElmer offers immunoassay technology platforms, pre-configured kits, and customizable reagents for superior results.



Better Microplates Means Better Results

A microplate is a critical part of your discovery process. Microplates have the capability to generate valuable, information-rich data that bring great insights into discovery screening.

Microplate planarity and inaccurate data collection are common issues caused by microplates that are not carefully designed for the unique challenges of sample screening which can result in missed data points, sample re-screening, missed project timelines, and ultimately higher costs.


Microplate Readers

PerkinElmer offers a family of plate readers focused on performance, versatility, and reliability for today's laboratory needs. Our drug discovery reagents are validated using our microplate readers, ensuring optimal performance when used together.


OnPoint Custom Solutions

Are you working on a novel target? Need to develop an assay? We’re here to help. Choose between custom labeling or custom assay development. Let our experts

  • Extend your lab's capabilities by labeling your sample so you can develop your own assay – Alpha, HTRF, LANCE Ultra and DELFIA labeling available.
  • Let us develop an assay to your specifications.


Explore Our Reagents By Target Area

Targeted Protein Degradation Assays & Reagents

Protein homeostasis in the cellular environment is achieved through the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal system (ALS). Together, th ...


Target Engagement Reagents

The pharmacological validation of the interaction of a ligand with its protein target is referred to as target engagement. Target engagement studies are crucial ...



从试验立项到初级和二级筛选,生物标记物分析过程中,珀金埃尔默的生物标记检测试剂和试剂盒具有高灵敏度、较宽的动态范围且便于实现自动化。 与市场上所有的ELISA或TR-FRET分析相比,由于无需洗涤及分离步骤,我们的均质技术能够最快的获得试验结果。


蛋白质 - 蛋白质相互作用

Accurately measure the function of proteins and gain new insights into protein-protein interaction (PPI) to modulate cellular processes. Inhibition and stabiliz ...



Cancer, diabetes, and Alzheimer’s research can benefit from the study of phosphorylation and protein kinase activity. Because of their role in signal transducti ...



G蛋白偶联受体(GPCR)是结构变化多样的一大类蛋白膜受体,包括:β1和β2肾上腺素能受体、多巴胺能受体和胆碱能受体。我们可提供G蛋白偶联受体研究所需的所有先进检测分析设备。 以及多种靶标Gs-、Gq-和Gi-偶联受体的实验试剂。 我们产品还包括: 荧光、发光或吸收光检测所需的可调焦GPCR细胞成像仪和液体工作站; 经 ...



To help unravel the complex biology of epigenetics, we provide a suite of enabling reagents and technologies that shorten assay development time and accelerate ...


Cytokine Research Reagents

Cytokines regulate several physiological and pathological roles including innate immunity, acquired immunity, and many inflammatory responses. PerkinElmer offer ...


Explore Our Reagents By Therapeutic Area

Immuno-oncology Reagents

Immuno-oncology is a leader in the worldwide drug development pipeline and is at the forefront of cancer research. By giving the immune system tools to detect t ...


Neuroscience Research Reagents

Over 55 million people worldwide are developing dementia and this number is expected to double by 2050. All the neurodegenerative disorders studies and associat ...



Achieve greater visibility into the mechanisms that cause cardiovascular disease using our phenotypic and target-based solutions. We offer a broad range of prod ...



Study targets of metabolic disease in vitro, in vivo and in situ using our biomarker detection kits, imaging systems and target-specific radiolabeled ligands, c ...


Virology Reagents

Viruses and virally transmitted diseases have been impacting human health and well-being for millennia. Some of our greatest scientific challenges and medical t ...


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