PerkinElmer

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Eliminate the need for antibodies and reduce assay time with direct detection using our radiolabeled ligands, which provide for sensitive and quantitative measurement of binding.

  • High specific activity — The majority of our 125I-labeled ligands are offered at maximum specific activity. This means virtually every molecule of ligand provided in the stock vial is radiolabeled. For tritiated ligands (3H ligands), pick a ligand with specific activity above 20 Ci/mmol – all of our tritiated ligands meets or exceeds these requirements.
  • High purity — We offer highly-pure radioligands for the highest specific signal with low background in binding assays.
  • High selectivity — Our broad portfolio of agonists and antagonists offers many options for choosing the most selective compound for your receptor.
  • Validated for receptor binding — all of our radioligand products are tested for receptor binding during development. Additionally, many of our radioligands are used to QC our GPCR and receptor cell lines and cell membrane products.

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应用
  • Drug Discovery & Development (103)
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浓度
  • 1.0 - 10 mCi/mL (57)
  • <1.0 mCi/mL (6)
  • 1 mCi/mL (4)
  • 1.0 - 10 µCi/mL (3)
  • 1.0 mCi/mL (1)
检测方法
  • Radiometric (106)
标签位置
  • Specifically Labeled (79)
  • Nominally Labeled (24)
  • Generally Labeled (6)
  • Uniformly Labeled (1)
产品品牌名称
  • NEN Radiochemicals (107)
放射性核素
  • 3H (102)
  • 14C (4)
  • 33P (1)
  • 3H (1)
  • 35S (1)
放射性同位素
  • H-3 (103)
  • C-14 (5)
  • P-33 (1)
  • S-35 (1)
受体类型
  • 5-Hydroxytryptamine (11)
  • Dopamine (10)
  • Opioid (9)
  • Adrenoceptors (9)
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  • Glucagon (1)
  • Potassium (1)
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  • CNS & Neurologic (80)
  • Cardiovascular (29)
  • Inflammation (26)
  • Pain (22)
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  • Metabolic Disorders (19)
  • Cancer (5)
  • Angiogenesis (3)
  • Diabetes (3)
  • Obesity (1)
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体积
  • 201-250 (57)
  • 0-50 (39)

"配体" 1-50110 产品与服务

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(+)-Pentazocine, [Ring-1,3-3H]

(+)-Pentazocine radioligand tritiated at the 1,3 position on the ring. Pentazocine is a synthetic opioid shown to bind sigma 1 receptor.

MDL105,519, [3H]

Tritiated MDL 105,519. MDL 105,519 acts as a potent and selective antagonist at N-methyl-D-aspartate (NMDA) receptors.

Ro 15-1788, [N-Methyl-3H]

Ro 15-1788 (flumazenil), tritiated on the N-methyl group. Ro 15-1788 acts as a selective benzodiazepine antagonist.

Mazindol, [4`-3H]-, 250µCi (9.25MBq)

Mazindol, tritiated at the 4' position. Mazindol has been shown to block dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters.

Neurotensin, [3,11-Tyrosyl-3,5-3H(N)]

Neurotensin radioligand tritiated at the 3,5 position of the tyrosine residues. Neurotensin is a neuropeptide that acts as an agonist on the neurotensin receptor family.

Vasopressin (8-L-Arginine), [Phenylalanyl-3,4,5-3H(N)]

Vasopressin, tritiated on the phenylalanine residue. Vasopressin binds and activates vasopressin receptors.

Histamine Dihydrochloride, [Ring, Methylenes-3H(N)]

Histamine dihydrochloride, tritiated on the ring and methylene groups. Histamine is an endogenous agonist of histamine receptors.

Raclopride, [Methoxy-3H]

Raclopride, [Methoxy-3H]- will have fresh lot dates on the second Monday in March and September.

AH5183, L-[PIPERIDINYL-3,4-3H]-(VESAMICOL), 250 µCi

AH5183 (vesamicol) radioligand tritiated at the piperidinyl-3,4 position. AH5183 is an acetylcholine transport blocker.

Deltorphin II (2-D-Ala), [Tyrosyl-3,5-3H]

Deltorphin II, tritiated at the tyrosyl-3,5 position. Deltorphin II is a selective δ opioid receptor (DOPR) agonist.

Norepinephrine Hydrochloride, DL-[7-3H(N)]-, 250µCi (9.25MBq)

DL-Norepinephrine hydrochloride, tritiated at the 7 position. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET).

Rosiglitazone, DL- [3H]-

Tritiated DL-Rosiglitazone (Avandia). Rosiglitazone acts as a selective agonist at peroxisome proliferator-activated receptors (PPARs).

Scopolamine Methyl Chloride, [N-methyl-3H]

Scopolamine methyl chloride, tritiated on the N-methyl group. Scopolamine acts as an antagonist at muscarinic acetylcholine receptors.

Pirenzepine, [N-Methyl-3H]

Pirenzepine, tritiated on the N-methyl group. Pirenzepine acts as a selective antagonist of the muscarinic M1 acetylcholine receptor.

Citalopram, [N-Methyl-3H]

Citalopram, tritiated at the N-methyl group. Citalopram is a selective serotonin reuptake inhibitor (SSRI) antidpressant drug, and has been shown to block the serotonin transporter (SERT, 5-HTT).

DOFETILIDE, [N-METHYL-3H], 100 µCi

Dofetilide, tritiated at the N-methyl position. Dofetilide is a selective potassium channel (hERG) blocker.

MK-801, (+)-[3-3H]-

(+)-MK-801 radioligand tritriated at the 3 position. MK-801 acts as a non-competitive antagonist at the glutamate receptor, N-Methyl-D-aspartate (NMDA).

Thyrotropin Releasing Hormone, [L-histidyl-4-3H(N), L-propyl-3,4-3H(N)]

Thyrotropin-releasing hormone (TRH), tritiated on the histidyl and propyl groups. TRH binds and activates thyrotropin-releasing hormone receptors (TRH-Rs).

Ketanserin Hydrochloride (R41 468), [Ethylene-3H]

Ketanserin hydrochloride (Sufrexal; R41468), tritiated on the ethylene group. Ketanserin is a high-affinity non-selective antagonist of 5-HT2 receptors.

Flunitrazepam, [Methyl-3H]

Flunitrazepam (Rohypnol), tritiated on the methyl group. Flunitrazepam is a benzodiazepine and acts as an agonist at GABAA (γ-aminobutyric acid) receptors.

Astemizole, [O-Methyl-3H]

Astemizole (Hismanal) tritiated at the O-methyl group. Atemizole is an antagonist of the histamine H1-receptor and has been shown to block hERG potassium channels.

Enkephalin, [Tyrosyl-2,6-3H(N)]- (2-D-Penicillamine, 5-D-Penicillamine) (DPDPE)

2-D-Penicillamine, 5-D-Penicillamine (DPDPE), tritiated on the tyrosyl group. Cyclic peptide, sequence: Tyr-D-Pen-Gly-Phe-D-Pen-OH. DPDPE is a synthetic enkephalin opioid peptide that acts as an agonist at delta opiate receptors (δ-opioid receptor, DOR). This product has a scheduled lot release for the second Monday in February and August.

TCP, [Piperdyl-3,4-3H(N)]

Tenocyclidine (TCP), tritiated at the piperdyl-3,4 position. TCP acts as an antagonist at N-methyl-D-aspartate receptor (NMDA receptors).

Colchicine, [ring C, Methoxy-3H]-, 250µCi (9.25MBq)

Colchicine, tritiated at the ring C methoxy- position. Colchicine binds tubulin to prevent microtubule polymerization, and is used to treat gout.

α-BUNGAROTOXIN,N-[3H]

α-Bungarotoxin (α-BTX) radioligand tritiated on the propionyl group. α-BTX acts as an antagonist at nicotinic acetylcholine receptors.

Verapamil Hydrochloride, [N-Methyl-3H]

Verapamil hydrochloride, tritiated on the N-methyl group. Verapamil acts as a calcium channel blocker (CCB).

Dihydroxyphenylethylamine, 3,4-[7-3H]

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the 7 position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors. This product has a scheduled lot release for the second Monday in April and October.

Hemicholinium-3 Diacetate Salt, [Methyl-3H]-, 250µCi (9.25MBq)

Hemicholinium-3 (HC3; hemicholine) Diacetate Salt, tritiated on the methyl group. Hemicholinium-3 blocks reuptake of choline by the high-affinity choline transporter. This product has a scheduled lot release for the second Monday in February and August.

5-CT, [3H]

5-carboxyamidotryptamine (5-CT) labeled with tritium. 5-CT is a tryptamine derivative closely related to the neurotransmitter serotonin. 5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 serotonin receptors. It also binds the 5-HT2, 5-HT3, 5-HT6 serotonin receptors with lower affinity.

5-Hydroxytryptamine Creatinine Sulfate, [1,2-3H(N)]

5-Hydroxytryptamine Creatinine Sulfate (Serotonin, 5-HT), tritiated at the 1,2 position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors.

Muscimol, 3-Hydroxy-5-Aminomethylisoxazole, [Methylene-3H(N)]

3H Muscimol radioligand. Muscimol acts as a potent selective agonist at GABAA receptors. It also acts as a partial agonist at GABAA-rho receptors. This product has a scheduled lot release for the second Monday in February and August. NOTE: NET574001MC will be obsolete soon.

Enkephalin (2-D-Alanine-5-D-Leucine), [Tyrosyl-3,5-3H(N)]-, 250µCi (9.25MBq)

DADLE, tritiated on the tyrosyl group. Peptide sequence: Tyr-D-Ala-Gly-L-Phe-D-Leu. DADLE is a synthetic enkephalin analog considered selective for the delta opioid receptor, but has been shown to bind the mu opioid receptor as well.

Iodoantipyrine, 4-[N-Methyl-14C]

4-Iodoantipyrine, labeled with C-14 on the N-methyl group. Iodoantipyrine has been used to measure cerebral blood flow.

Norepinephrine, Levo-[7-3H]

Levo-Norepinephrine, tritiated at the 7 position. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET). This product has a scheduled lot release for the third Monday in July.

WIN 35428, [N-Methyl-3H]

WIN 35428 [(–)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane], tritiated on the N-methyl group. WIN 35428 acts as an antagonist at dopamine transporters (DATs).

(+/-) Epibatidine, [5,6-Bicycloheptyl-3H]

(+/-)-Epibatidine radioligand tritiated at the 5,6-biocycloheptyl position. Epibatidine has analgesic activities, has been shown to function as an agonist at nicotinic acetylcholine receptors, and has been shown to bind muscarinic and serotonin 5-HT3 receptors.

Kainic acid, [Isopropenyl-3H]

Kainic acid, tritiated on the isoproprenyl group. Kainic acid acts as an agonist at kainate glutamate receptors.

MK-912, [3H(G)]

MK-912 radioligand. MK-912 acts as a selective antagonist at the α2-adrenoceptor. This product has a scheduled lot release for the second Monday in October. NOTE: NET1227025UC will be obsoleted soon.

Diltiazem, cis-(+)-[N-Methyl-3H]

cis-(+)-Diltiazem, tritiated at the N-methyl position. Diltiazem is a non-DHP calcium channel blocker.

Chloramphenicol, [Ring-3,5-3H]

Chloramphenicol, tritiated at the ring-3,5 position. Chloramphenicol is a broad spectrum antibiotic that binds to a receptor site on the 50S subunit of the bacterial ribosome, inhibiting peptidyl transferase.

Vinblastine Sulphate, [G-3H]

Vinblastine sulphate, tritiated. Vinblastine binds to tubulin and inhibits microtubule formation.

GR 65630, [N-Methyl-3H]

GR 65630, tritiated on the N-methyl group. GR 65630 acts as a selective antagonist at the 5-HT3 receptor.

Paroxetine, [Phenyl-6'-3H]

Paroxetine (Paxil), tritiated at the phenyl-6' position. Paroxetine is a selective serotonin reuptake inhibitor (SSRI). This product has a scheduled lot release for the first Monday in May and November.

Dihydroxyphenylethylamine [2,5,6,7,8-3H] (Dopamine)

Dihydroxyphenylethylamine (dopamine) radioligand tritiated at the 2,5,6,7,8 position. Dopamine functions as a neurotransmitter that binds dopamine receptors.

Diprenorphine [15,16-3H]

Diprenorphine (Revivon; M5050; diprenorfin), tritiated at the 15,16- position. Diprenorphine acts as a non-selective antagonist at opioid receptors.

NALOXONE, [N-ALLYL-2,3-3H]-

Naloxone radioligand tritiated at the 2,3 position. Naloxone acts as a non-selective, competitive opioid receptor antagonist.

DAMGO, [Tyrosyl-3,5-3H(N)]

DAMGO, tritiated at the tyrosyl 3,5 poisition. DAMGO is a synthetic opioid analog with high specificity for the μ-opioid receptor.

Prazosin, [7-Methoxy-3H]

Prazosin, tritiated at the 7-methoxy position. Prazosin acts as an inverse agonist at the α1-adrenergic receptor.

RO 15-4513, [7,9-3H]-, 250µCi (9.25MBq)

Ro15-4513, tritiated at the 7,9 position. Ro15-4513 is a partial inverse agonist at GABAA receptors.

Dihydroalprenolol Hydrochloride, Levo-[Ring, Propyl-3H(N)]

Dihydroalprenolol hydrochloride, tritiated on the ring propyl group. Dihydroalprenolol (DHA) is an alprenolol derivative that binds to beta-adrenergic receptors and acts as a beta-adrenergic blocker.

"配体" 1-50110 产品与服务

每页