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Cytisine HCl, [3,5-3H(N)]-, 250µCi (9.25MBq)

Cytisine HCl, [3,5-3H(N)]- will have fresh lot dates on the second Monday in April.


25 µCi
250 µCi




详情 信息

Cytisine is a partial agonist of nicotinic acetylcholine receptors. These receptors are responsible for motor nerve-muscle communication, and are involved in the peripheral and central nervous system. The are potential drug targets for depression, cognitive disorders, pain, epilepsy, smoking cessation, anxiety, and neurodegenerative diseases.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1054:

  1. L A Pabreza, S Dhawan and K J Kellar. [3H]cytisine binding to nicotinic cholinergic receptors in brain. Molecular Pharmacology January 1, 1991, 39 (1): 9-12.
  2. D J Anderson, S P Arneric, Nicotinic receptor binding of [3H]cytisine, [3H]nicotine and [3H]methylcarbamylcholine in rat brain, In European Journal of Pharmacology, 1994, 253 (3): 261-267.


检测方法 Radiometric
新鲜的很多天 2nd Monday in April
标签位置 Nominally Labeled
分子量 226.7
产品品牌名称 NEN Radiochemicals
放射性同位素 H-3
放射性核素 3H
受体类型 Nicotinic
运输条件 干冰
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 CNS & Neurologic, Pain, Inflammation
产品尺寸 250 µCi