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Vasopressin, [125I]Tyr2, Arg8-, 50µCi (1.85MBq)

Vasopressin, labeled with 125I on tyrosine residue 2. Vasopressin binds and activates vasopressin receptors, a group of GPCRs that are potential drug targets for hyponatremia, congestive heart failure, and cirrhosis.

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产品尺寸
NEX128010UC
10 µCi
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NEX128050UC
50 µCi
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详情 信息

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX128:

  1. Thiesson, H.C., Skøtt, O., Jespersen B., Schaffalitzky de Muckadell, O.B. (2003), Nitric Oxide Synthase Inhibition Does Not Improve Renal Function in Cirrhotic Patients With Ascites, American Journal of Gastroenterology 98, 180–186.
  2. Lishajko F, Appelgren B, Eriksson S. (1981) Cerebral sodium/angiotensin interaction studied by RIA-determination of urinary arginine vasopressin in the hydrated goat. Acta Physiol Scand. 111(3):311-8.

规格

检测方法 Radiometric
新鲜的很多天 Second Monday of each month
标签位置 Nominally Labeled
产品品牌名称 NEN Radiolabeled Ligands
放射性同位素 I-125
放射性核素 125I
受体类型 Vasopressin
运输条件 干冰
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 CNS & Neurologic, Metabolic Disorders
产品尺寸 50 µCi
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Using the NENSure Packaging System from PerkinElmer

Since 1985, the unique NENSure system has set the standard for radiochemical packaging. Based on proven performance over millions of shipments, the system provides: Ease of use, Safe storage of unused product and Reduced radiation exposure. Many NEN brand research products, including 32P-, 33P-, 35S-, 3H-, 14C- and 125I-labeled compounds, are packaged in the NENSure System, as are most radionuclides.

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