PerkinElmer与哈勃,为人类打磨一双慧眼
在历史长河中,人类对于头顶上这片星空的探索从公元前开始就从未停止过。古希腊先人用自己丰富的想象力和浪漫情怀为夜晚的星空划分出一个个星座,寄寓着一个个动人的神话故事。而现代人类早已不满足于用想象力去定义这浩瀚的宇宙,人们渴望着用自己的眼睛更真实地感知我们生活的宇宙空间。
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It has long been thought that mitochondrial defects play an important role in the development and progression of cancer. Many of the cell growth and survival pathways targeted by anti-cancer drugs are mediated through mitochondria. However, it is not known how changes in mitochondrial shape and organization can lead to cancer, or how the altered form of cancer cell mitochondria can be exploited for therapeutic benefit.
Researchers Dr. Chris Bakal and Dr. Julia Sero from the Institute of Cancer Research in London are quantifying the effects of anti-cancer drugs on mitochondria in breast cancer cells.
By better understanding mitochondrial biology in cancer, they hope that knowledge from their research may contribute towards the design of new strategies for cancer prevention, diagnosis, and potential treatments.
Mitochondria, small organelles found in a cell, are complex networks that are highly variable, both between cell lines and within cell populations. They play a variety of important roles in cell physiology, such as regulating cellular processes and cell death.
Mitochondria undergo dramatic changes as cells grow, divide, and die, and mutations that affect mitochondria can affect the cell's sensitivity to stimuli. However, the relationship between mitochondrial structure and function remains unclear.
"I began working with the Opera® system as a postdoctoral fellow at Harvard, and wanted to bring the same technology to the ICR at London because I believe it is really the only microscope on the market that is capable of generating high quality images in high throughput."
To measure diverse changes in mitochondria as cells are exposed to different anti-cancer drug compounds, Dr. Bakal and Dr. Sero use the Opera® High Content Screening System for imaging and the Columbus™ Image Data Storage and Analysis System for analysis of mitochondrial structures. "I had used the Opera system in a previous laboratory," said Dr. Bakal, "and wanted to bring the same technology to my current research because I believe it is really the only microscope on the market that is capable of generating high quality images in high throughput."
The Opera System enables Dr. Bakal and Dr. Sero to capture high-quality images rapidly, and in high throughput. By pairing it with the Columbus system, which provides high-volume image data storage and analysis, they are able to detect any subtle changes in the mitochondria. Hundreds of texture and morphological parameters such as cell area, roundness, length, width and symmetry are typically measured.
Dr. Bakal and Dr. Sero have found that using the Opera and Columbus systems for analysis let them distinguish not only the effects of different compounds on mitochondrial organization, but also the effects of two doses of the same drug. They have also showed that automated image analysis enables detection of more subtle changes in cells than human observers can find. Their methods will allow other researchers to analyze the degree of heterogeneity within groups, to detect subpopulations, and to measure the percentage of cells that are affected by the compounds being studied.
For Research use only. Not for use in diagnostic procedures.
在历史长河中,人类对于头顶上这片星空的探索从公元前开始就从未停止过。古希腊先人用自己丰富的想象力和浪漫情怀为夜晚的星空划分出一个个星座,寄寓着一个个动人的神话故事。而现代人类早已不满足于用想象力去定义这浩瀚的宇宙,人们渴望着用自己的眼睛更真实地感知我们生活的宇宙空间。
2019昆明国际肿瘤研究论坛在昆明顺利召开,本届会议邀请了国内外癌症研究领域顶尖的华人学者们齐聚一堂,共襄盛会,围绕“癌症基础研究和临床治疗”的主题,共同分享与探讨了癌症发生、发展和治疗的新知识和远见。
珀金埃尔默对创新的承诺是建立在公司的科学家和研究人员的伟大工作之上的,是他们的研究成果建立了珀金埃尔默在人类和环境健康领域的市场领先优势。
Milano-Bicocca大学环境科学系的Giovanni Baccolo博士和他的同事研究分析南极冰芯样品,重点在于分析包裹在冰中的大气矿物颗粒,俗称“尘埃”。
我是来自珀金埃尔默的ChemDraw,我为化学绘图代言!