QSight Triple Quad LC-MS/MS 400 Series | PerkinElmer
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QSight LC/MS/MS System

More than ever, laboratories analyzing food and environmental samples are faced with evolving challenges with stricter regulations demanding lower detection limits and higher levels of productivity. Lab operations need to be optimized, without any compromise on analysis confidence and accuracy.

With the PerkinElmer QSight® Triple Quad LC/MS/MS labs can test for the most challenging samples with maximized uptime and confidence. The unique dual-source configuration enables high-throughput labs to collect data in two complementary modes, maximizing the output from a single injection. Combined with the StayClean technology dramatically reduced source cleaning and maintenance, translating into higher productivity and high ROI. Running on the PerkinElmer Simplicity 3Q Software, the PerkinElmer QSight Triple Quad LC/MS/MS is easy-to-learn and use and it is a complete solution streamlining the complete workflow, from validated method development to data reporting.

Part Number
Model Name
BC003844
QSight 420 LC/MS/MS
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BC003382
QSight 220 LC/MS/MS
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BC003383
QSight 210 LC/MS/MS
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BC003265
QSight 110 LC/MS/MS
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Overview

The QSight LC/MS/MS System provides the capability and confidence required to analyze the most complex food and environmental samples. With high level of sensitivity and throughput, laboratories can meet even the most stringent regulatory requirements rapidly, easily, and effectively

  • Sensitivity for the most demanding regulations
  • Easy-to-use with ready to implement methods
  • Patented flow-based technology that enables up to 15% more productivity
  • StayClean Source, self-cleaning design for maximum sensitivity and exceptional uptime
  • Laminar Flow Ion Guide for highly efficient field-free transmission, providing virtually no maintenance requirements
  • Dual Source technology gives you the capability to set ESI or APCI modes, with two independent probes for true multiplexing
  • Modular Simplicity 3Q Software to acquire, quantify, and report with flexible data viewing options and powerful remote diagnostics.
  • Different models available (QSight 110 LC/MS/MS, QSight 210 LC/MS/MS, QSight 220 LC/MS/MS, QSight 420 LC/MS/MS) addressing different levels of performance and efficiency required by different labs’ analysis needs.

Specifications

Model Name QSight 420 LC/MS/MS
Resources, Events & More
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Application Note

A Multiclass Multiresidue Method for Analysis of Veterinary Drugs in Chicken by UHPLC/MS/MS

Veterinary drugs are used in animal production to treat diseases, prevent infection and protect growth of animals, which helps provide quality marketplace. However the uncontrolled use may cause heavy human disease so regulatory agencies around the world have established maximum residue levels (MRLs ...

PDF 1 MB
Analysis of Acrylamide in Potato Chips by Isotopically Standard Addition UHPLC-MS/MS

Acrylamide is a probable carcinogen organic compound that is found in some foods that are cooked at elevated temperatures. It’s origins are due to the condensation of the amino acid asparagine and glucose as part of Maillard reaction. In 2002, Acrylamide was found to be present in french fries and b ...

PDF 1 MB
Analysis of Aflatoxins by UHPLC

Aflatoxin B1 is considered to be the most genotoxic of the mycotoxins, and, when ingested by cows, is converted to aflatoxin M1 which has been shown to cause liver cancer in certain animals.

PDF 1 MB
Analysis of Challenging Polar Contaminants in Water by LC/MS/MS with Direct Injection

Several directives throughout the EU provide guidance on environmental quality standards for water, and define more than 30 priority substances as significant risk to humans. Many of the monitoring limits within these directives are set at low µg/L (ppb) levels, and as such, require highly sensitive ...

PDF 1 MB
Analysis of Mycotoxins in Multi-Grain and Corn Cereals

Mycotoxins produced by fungi as toxic secondary metabolites, leave grains, maize and cereals particularly vulnerable. With this in mind, and considering that an estimated 25% of all crops show some signs of mycotoxin contamination, many countries have established regulatory guidelines for maximum my ...

PDF 991 KB
Analysis of PFAS in Drinking Water by Large Volume Direct Injection Following the EU Drinking Water Directive 2020/2184

This application note highlights the LC/MS/MS analysis of PFAS compounds according to the European Union Water Framework Directive 2020/2184. It demonstrates how the PerkinElmer QSight® 420 LC/MS/MS System using a large volume direct injection can determine and quantify the latest 20 PFAS compounds ...

PDF 1 MB
Analysis of illegal dyes in Chili Spices via UHPLC-MS/MS

Since 2003 the usage of azo and non-azo dyes for food coloring has been declared as illegal by many of the food international authorities across the globe. That is because these substances such as Sudan I,II,III,IV and Rhodamine B, are potentially carcinogens and genotoxin in nature. As of now, no o ...

PDF 4 MB
Analysis of near 400 Pesticides in Tea Via LC/MS/MS

With routine labs tasked with the analysis of larger and larger target lists, and with greater numbers of samples requiring analysis, we deployed simple sample preparation protocols such as solvent extraction to meet the need of high sample throughput with lower cost. In this work, we demonstrate ho ...

PDF 1 MB
Application Compendium - Analytical Solutions for Pesticides Analysis

The increasing demand for organic products, evolving global regulations, and improving accessibility of agricultural hubs to global markets results in pressure on food safety precautions. Translating, in part, to increased pesticide residue analysis demand. Mass spectrometry meets pesticide analysis ...

PDF 6 MB
PDF 1 MB
Efficient LC/MS/MS Method for Testing Hemp Samples for Pesticide Residues

Agricultural growing of hemp products for the purposes of cannabidiol (CBD) extraction was legalized in the United States with the passing of the Agricultural Improvement Act of 2018. Since the act passed, heightened concern over the use of pesticides in hemp production has been appreciated. However ...

PDF 1 MB
Fast and Targeted Analysis of Cell Culture Media Components using QSight LC/MS/MS

Quantitative analysis of cell culture media components is a critical step in upstream bioprocess development. A comprehensive and quantitative understanding of cellular metabolic components could lead to a greater understanding of the process impacts on cell growth, productivity, and product quality ...

PDF 1 MB
High Sensitivity Analysis of Estrogens in Water and Urine by Direct Injection UHPLC/MS/MS

Estrogen plays an important role in the human body, but excess concentrations of endogenous estrogens, a known endocrine disrupting compound (EDC), in urine have been linked to the development and growth of breast cancer and tumors in females. Endogenous estrogens, including estrone (E1), 17ß-estrad ...

PDF 1 MB
LC/MS/MS Analytical Method for Pesticide Residue in Cannabis Flower as Defined by Florida Testing Requirements

This application note outlines a new workflow with one instrument platform (LC/MS/MS) method that is ideal for simultaneous analysis of pesticide and mycotoxins residue in cannabis. This application note demonstrates the performance of a LC/MS/MS ESI and APCI method with a single solvent extraction ...

PDF 2 MB
LC/MS/MS: Analysis of Perfluoroalkyl and Polyfluoroalkyl Substances in Aqueous Samples by EPA Method 1633

Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals developed in the 1940s, and widely used for their surfactant properties. Due to their prevalent use within consumer products and persistence in nature, PFAS have leached into the air, soil, and water, making exposure wides ...

PDF 1 MB
LC/MS/MS: Improved Throughput and Flexibility for Compliant Drinking Water Analysis with Dual Source Capability

Governing bodies have implemented various directives to monitor acrylamide in drinking water. This also applies in the European Union where the water framework directive and subsequent daughter directives have defined many priority substances, including acrylamide. Compounds chlorate, perchlorate an ...

PDF 1 MB
Measurement of Cortisol & Cortisone in Urine

Simultaneous detect and quantify cortisol and cortisone in urine using the QSight 200 series mass spectrometer coupled with a commercially available kit.

PDF 615 KB
Measurement of Remdesivir & Its Metabolite GS-441524 in Plasma

Sensitive and accurate determination of remdesivir and GS-441524 in human plasma samples for pharmacokinetic and pharmacodynamic studies of remdevisir.

PDF 599 KB
Method Validation for Atrazine Analysis in Fresh, Atypical Mineral and Carbonated Waters

EU water policies are reevaluated on a consistent basis to ensure water sources do not contain contaminants at levels above regulatory levels. As regulations are reviewed, regulatory limits are often lowered, and analytical techniques must adapt to meet the new stringent requirements. In this applic ...

PDF 1 MB
Novel ESI and APCI LC/MS/MS Method for Testing Cannabis and Hemp Concentrate Samples

The use of cannabis concentrates and CBD products (edibles, topicals, vape products, etc.) has increased in popularity as new regulation has been passed legalizing medicinal and recreational use in a number of states and provinces. Testing to ensure that pesticide and mycotoxin levels in cannabis pr ...

PDF 1 MB
Pesticide in Grapes by LC-MS/MS

The Grape crop is one of the most important fruit crops consumed in the world. Grapes are consumed both as fresh and as processed products, such as wine, jam, juice, jelly, grape seed extract, raisins, vinegar and grape seed oil. A large variety of pesticides are used in grape production throughout ...

PDF 1 MB
Polymer Applications Compendium

Today’s plastics are some of the most used materials on a global volume basis. Broadly integrated into today’s industrial and commercial lifestyles, they make a major, irreplaceable contribution to virtually every product category. In this compendium you will find a wide range of applications for po ...

PDF 57 MB
Quantitation of Microcystins and Nodularin in Drinking Water Samples to Meet EPA Method 544 Requirements Using QSight LC/MS/MS

Cyanotoxins often exist intracellularly in cyanobacteria and are released into the water when cells die. Blooms caused by cyanobacteria can be harmful to the human health, animals, and the environment. Microcystin-LR (MC-LR) is one of the most common cyanotoxins and ingestion will cause negative hum ...

PDF 901 KB
Rapid Analysis of Haloacetic Acids in Drinking Water Using UHPLC/MS/MS

Haloacetic acids (HAAs) are a class of undesired by-products resulting from the reaction of chlorinated disinfectants with natural organic matter in water, Which is known to be carcinogenic. The Japan Ministry of Health revised the inspection method for HAAs, which led to expansion of the analytical ...

PDF 1 MB
Rapid and Sensitive Analysis of 17 Per-and Polyfluoroalkyl Substances in Water by Direct Injection with QSight 420

Per- and polyfluoroalkyl substances (PFAS) are a diverse group of synthetic organic compounds which have been utilized as aqueous film forming foams (AFFF) for firefighting purposes, and as stain and water resistant coatings on a number of consumer products such as clothing, furniture or cookware. P ...

PDF 3 MB
Simple and Sensitive Method for Determination of Ochratoxin A in Wine by LC/ MS Using QSight Technology

Ochratoxin A (OTA) is a secondary metabolite produced by Penicillium and Aspergillus fungi species found in soil and organic matter, and is one of the most widely reported of the nearly 400 recognized mycotoxin contaminants of agricultural products. OTA can enter the human food chain through contami ...

PDF 924 KB
Simultaneous Detection of Estrogenic and Progestogenic Hormones in Edible Bird's Nest

This application note presents a sensitive and reliable LC/MS/MS method using the PerkinElmer QSight

PDF 859 KB
Simultaneous Determination of Pesticides Residues and Illegal Additives in Wine

Wine can often contain pesticides and fungicides that have been sprayed on the fruits during their growing period. In addition to these contaminants, wine can also contain additives that have been deliberately added during production processes to improve its flavor and color. In this study, a simple ...

PDF 1006 KB

Article

Driving Lab Efficiency and Performance Acceleration with LC/MS/MS

The COVID-19 pandemic impacted industries, economies, and lives, and brought about the need for a new approach for contract testing laboratories working in different application fields. Considering the directions shaping the laboratory industry, this article revises trends that could be also applied ...

PDF 438 KB

Brochure

Productivity to the Power of Two - QSight LC/MS/MS System Brochure

When analyzing food and environmental samples, laboratories often need multiple system to get the qualitative and quantitative information on contaminants. But this can result in duplicated sample preparation processes, increased cost of ownership – and suboptimal lab efficiency. Discover the unique ...

PDF 3 MB
QSight Pesticides Analyzer Brochure

Pesticides can adversely affect human health through the food we consume but can also leach into soil and groundwater and impact us through the environment. To keep up with a complex and constantly changing regulatory environment, your pesticide analysis solution needs to keep up with your burgeonin ...

PDF 9 MB

Ebook

What's in Your Water? PFAS Analysis Explained

Over the past decade, awareness and concern about Per- and Polyfluoroalkyl Substances (PFAS) has grown and led to more in-depth analysis of these compounds and the effects that they can have on human health. Due to their inert nature, PFASs are persistent organic pollutants and have been found to ac ...

PDF 1 MB

Guide

Tips for Launching a Modern Cannabis Testing Lab

Demand for cannabis testing services continues to climb as more US states and countries around the globe implement regulated adult-use markets. The cannabis testing sector in the US, like many facets of the cannabis industry, is challenged by the complexity of working with a federally illegal but st ...

PDF 285 KB

Product Note

PDF 890 KB
QSight Simplicity 3Q Software Suite

Our modular Simplicity 3Q™ software is ideal for acquiring, quantifying and reporting

PDF 1 MB

Regulatory Compliance Certification

Product Certificate - QSight 300/400 Series

Product Certificate for the QSight 300/400 Series

PDF 135 KB

Technical Note

Flow Characteristics of a Laminar Flow Interface for LC/MS/MS

Simulation using sophisticated modeling techniques has become a powerful tool for mass spectrometry

PDF 1 MB
Ion Transmission Through a Quadrupole Ion Guide

Ion Transmission Through a Quadrupole Ion Guide Under the Combined Influence of Viscous Flow and RF

PDF 1 MB

Video

From Contamination to Productivity: PerkinElmer StayClean Technology

Analytical laboratories face many challenges when analyzing contaminants such as Pesticides, PFAS, mycotoxins in complex matrices. These samples often require time-consuming sample prep and regular maintenance of the analytical technology.

Video
Overcoming PFAS Challenges - Method Development for Changing PFAS Regulations

Due to PFAS persistence in the environment and potential health risks, regulations have been undergoing constant change and refinement.

Video
Customer Spotlight: Pride Analytics

With our extended portfolio of cannabis testing products featuring best-in-class sample homogenization platforms, ICP-MS, LC/MS-MS, Headspace-GCMS, UHPLC and FTIR instruments and consumables, we help drive analytical best practices and operating procedur

Video
Overcoming PFAS Challenges – Mitigating Matrix-Induced Ion Source Contamination

PFAS matrix-induced contamination poses various challenges for analytical laboratories, from the risk of achieving low detection limits and lab downtime.

Video
Overcoming PFAS Challenges - Minimizing Sources of Contamination

PFAS compounds are ubiquitous throughout the environment and accumulate everywhere, including in the lab.

Video
Mitigate Interference and Contamination in PFAS Analysis

As per- and polyfluoroalkyl compounds become more prominent, the US Environmental Protection Agency (EPA) are developing more stringent regulations for PFAS monitoring.

Video
Efficient, Robust and reliable performance for LC/MS/MS Analysis

Stricter regulations demanding lower detection limits, increased throughput and efficiency demand that labs need an LC/MS/MS solutions that offers robust and reliable performance while ensuring efficiencies.

Video
Analyzing the Unanalyzable: Breakthrough in Complex Samples with LC/MS/MS

When examining complex compounds like PFAS, pesticides, and mycotoxins using LC/MS/MS in challenging matrices, laboratories encounter issues such as system contamination, matrix effects, and the laborious task of source cleaning.

Video
Customer LC/MS/MS Spotlight: Professor Sabra Botch-Jones

The PerkinElmer QSight LC/MS/MS is used for many applications, including forensic toxicology.

Video

Webinars

LC-MS Tips & Tricks

In this presentation, prepare to learn all of the best practices for Liquid Chromatography Mass Spectrometry from consumables all the way to instrumentation and analysis. This talk is well-suited for all LC/MS applications including environmental testing

Webinars
Analysis of 102 Pesticide and 5 Mycotoxin Residues In Hemp Regulated By Colorado State

In this latest webinar, LC–MS/MS PerkinElmer expert Dr. Avinash Dalmia describes how LC–MS/MS based systems and methods can overcome the challenges associated with the analysis of pesticides and mycotoxins regulated by Colorado state in hemp with dual ES

Webinars
What’s in Your Water? Monitoring Cyanotoxins in Drinking Water by LC-MS/MS

Growing environmental concern has led to stricter regulations of drinking water and water supplies over the past decade including routine monitoring and detection of cyanotoxins resulting from ever-growing algae blooms. This talk discusses the utiliza

Webinars
Critical Insights in the Detection of PFAS in our Environment

PerkinElmer offers a portfolio of high-performance solutions to optimize your laboratory workflow for PFAS analysis.

Webinars
What’s in Your Water? Monitoring Pharmaceuticals and Personal Care Products in Drinking Water by LC-MS/MS

Pharmaceutical and personal care products (PPCPS) are an emerging environmental concern and include human and veterinary prescriptions, over-the-counter medications, sunscreens, lotions, soaps and insect repellents. In this webinar we demonstrate the a

Webinars
QSight LC-MS/MS in Toxicology Research at Boston University

In this podcast, we meet with Simone Rumph, a first generation college student, to discuss her research on post-mortem drug identification.

Webinars
Conquering PFAS Compliance with Simplified Implementation and Robust LC/MS/MS Workflows

In this short webinar, PerkinElmer’s Environmental Leader, Tom Hey, discusses simplified PFAS method implementation with the comprehensive PerkinElmer LC/MS/MS workflow, featuring ready-to use consumables kits, reagents and software-driven compliance.

Webinars
Optimizing Workflow and Efficiency in the Analysis of Emerging Contaminants, Including PPCPs and PFAS

Emerging contaminants, including perfluoroalkyl surfactants (PFAS) and Pharmaceuticals and Personal Care Products (PPCPs), have garnered increasing interest in recent years as their bioaccumulative nature and endocrine disrupting potential have become..

Webinars
Complex Matrices: How the PerkinElmer QSight LC/MS/MS can help tackle the toughest samples

When it comes to analyzing environmental or food samples, including water, soil, cannabis or any solid matrices, labs need to meet stricter regulations that demand lower detection limits.

Webinars
What’s in your Water? Monitoring of PFAS in Drinking Water According to EPA Method 537.1

The US EAP Method 537.1 is used for the determination of selected PFASs in drinking water by solid phase extraction and liquid chromatography/tandem mass spectrometry. This talk discusses the utilization of the PerkinElmer QSight® Triple Quadrupole LC

Webinars

White Paper

Mitigation of PFAS in Drinking Water Through Analytical Innovation

Per- and polyfluoroalkyl substances (PFAS) have gained significant attention as an emerging environmental and safety threat in the United States. Since the 1940s, PFAS are ubiquitous in industrial usage due to their chemical stability, thermal stability, and high resistance to degradation. Bioaccumu ...

PDF 900 KB