When analyzing food, and environmental samples, laboratories need multiple system to get the qualitative and quantitative information on contaminants, resulting in duplicated sample preparation processes, increased cost of ownership and sub-optimal lab efficiency. The unique dual-source configuration of the PerkinElmer QSight® LC/MS/MS System enables high-throughput labs to collect data in two complementary modes (ESI and APCI), maximizing the output from a single injection. Combined with the StayClean™ technology, source cleaning and maintenance is dramatically reduced, translating into higher productivity and ROI. The easy-to-learn PerkinElmer Simplicity™ 3Q Software, streamlines the complete LC/MS/MS workflow, from validated method development to data reporting.
Exploit the productivity for your lab with the QSight LC/MS/MS System.
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Less Sample Prep. More Productivity
Tackle the toughest food matrices with minimal sample preparation and maximum efficiency. Whether dealing with fatty avocados or aqueous tomatoes, Blend & Inject transforms complex samples into clean, reliable, and actionable data—without the need for extensive extraction or cleanup.
Designed to work seamlessly with the PerkinElmer QSight 500 LC/MS/MS, this streamlined approach enhances throughput while maintaining sensitivity at levels far below the regulatory limits. Comparable results to QuEChERS, but with a fraction of the prep time. With the robustness of QSight StayClean Technology, Blend & Inject minimizes downtime, optimizes resources, and keeps your lab running smoothly.
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StayClean HSID Interface: Cleaner, More Reliable Performance
Say goodbye to frequent maintenance and hello to uninterrupted performance. The StayClean HSID Interface is designed to keep your instrument running smoothly with minimal upkeep.
Unlike traditional systems that can accumulate contamination over time, our innovative heated inner surface prevents buildup, while a hot laminar flow ensures efficient desolvation of charged species. This means enhanced ion transmission, greater signal stability, and long-term reliability—so you can focus on your work, not on cleaning.
Experience a smarter, more efficient way to analyze - because your time is valuable.
Resources

Unmatched Robustness for Analysis of Per- and Poly-fluoroalkyl Substances in Difficult Food Matrices
In food safety testing, instrument reliability under real-world conditions is the true test of performance. This technical note showcases the durability and consistency of the PerkinElmer QSight® 500 LC/MS/MS system through an intensive robustness study, analyzing high-matrix food samples with minimal cleanup and no loss in sensitivity.
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Analysis of 40 Per- and Polyfluoroalkyl Substances by US EPA Method 1633
Part 1: Method Development and Verification with Quality Control Samples
In this first installment of a 4-part application note series, we detail a validated LC-MS/MS workflow for the analysis of 40 targeted PFAS compounds in water samples using PerkinElmer QSight® 500 LC/MS/MS system and an automated solid-phase extraction (SPE) platform.
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Analysis of 40 Per- and Polyfluoroalkyl Substances by US EPA Method 1633
Part 2: Application to Surface Water and Wastewater Samples
PFAS contamination in surface water and wastewater is a growing global concern, prompting the need for sensitive, efficient, and EPA-compliant analytical solutions. This is Part 2 of a 4-part application note series showcasing a robust LC-MS/MS workflow aligned with US EPA Method 1633, now applied to real-world water samples.
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Analysis of 40 Per- and Polyfluoroalkyl Substances by US EPA Method 1633
Part 3: Application to Sand, Soil, Sediment, Sludge, Biosolid and Other Solid Samples
From remediation sites to agricultural lands, testing PFAS in solid samples is no longer optional; it’s essential. Part 3 of this 4-part application note series details a comprehensive LC-MS/MS workflow for the analysis of 40 PFAS compounds in soil and sediment, fully aligned with US EPA Method 1633.
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Analysis of 40 Per- and Polyfluoroalkyl Substances by US EPA Method 1633
Part 4: Application to Fish and Other Animal Tissue Samples
Monitoring PFAS in biological samples like fish and animal tissue is essential for food safety and environmental risk assessment, but it presents unique challenges due to complex matrices and variable recoveries. Part 4 of this 4-part application note series demonstrates a validated sample prep and LC-MS/MS workflow tailored to meet these challenges while complying with US EPA Method 1633.
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QSight 500 LC/MS/MS System
Built for sludge, grease, and the nastiest matrices you can throw its way. With unmatched robustness and minimal sample prep, the QSight® 500 LC/MS/MS System tr ...
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Customer LC/MS/MS Spotlight: Professor Sabra Botch-Jones
The PerkinElmer QSight LC/MS/MS is used for many applications, including forensic toxicology.
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Improved Throughput for the Analysis of Perfluoroalkyl and Polyfluoroalkyl Substances in Drinking Water by EPA Method 533
Growing health concerns regarding Per- and polyfluoroalkyl substances (PFAS) and their prevalence in consumer goods and the environment indicates a critical nee ...
Learn MoreExplore Our Liquid Chromatography Mass Spectrometry Portfolio
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QSight 500 LC/MS/MS System
Designed to tackle the challenges faced by environmental testing labs analyzing PFAS and other emerging contaminants, the QSight® 500 LC/MS/MS System provides a robust solution for handling complex matrices.
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LC/MS Instruments
No matter what your application or matrices, our liquid chromatography and mass spectrometry (LC/MS) systems deliver the speed, sensitivity, exact mass information, wide dynamic range, and mass accuracy you need for having complete confidence in your results.
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Chromatography & Mass Spectrometry Software
Demanding chromatography applications, from QA/QC to research, need to be supported by powerful software that addresses the need for ease-of-use and different proficiency levels.
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Chromatography Consumables & Accessories
PerkinElmer is committed to providing reliable consumables that support chromatographers across the globe. We supported the growth of chromatography into the wide-spread technique it has become, and we're still here serving separation scientists today.
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