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Introduction

Per- and polyfluoroalkyl substances (PFAS) are among the most persistent and scrutinized environmental contaminants today, demanding highly sensitive and reliable testing methods.

In this first installment of a 4-part application note series, we detail a validated LC-MS/MS workflow for the analysis of 40 targeted PFAS compounds in water samples using PerkinElmer QSight® 500 LC/MS/MS system and an automated solid-phase extraction (SPE) platform. Developed in accordance with US EPA Method 1633, this workflow delivers exceptional sensitivity, reproducibility, and operational robustness.

Explore method development, calibration, and performance verification using QC and PT samples. Optimized chromatography and large-volume injection support low ng/L detection and high-throughput workflows.

  • Includes sample prep, instrument setup, and QC validation
  • Achieves LOQs and MDLs aligned with EPA Method 1633
  • Designed for environmental labs and contract testing facilities

Download Part 1 now to explore method optimization strategies, validation protocols, and best practices for reliable PFAS quantification. Parts 2–4 will cover additional sample matrices including wastewater, animal tissue, solids, and biosolids.

 

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